In the fruit fly, Drosophila melanogaster, the larval somatic muscles or the adult thoracic flight
and leg muscles are the major voluntary locomotory organs. They share several …

Signal transduction through multiple distinct pathways regulates and orchestrates the
numerous biological processes comprising heart development. This review outlines the …

Although Cisplatin (DDP) is a widely used first-line chemotherapy medication, DDP
resistance is one of the main causes of treatment failure in advanced lung cancer. Therefore …

Elucidation of the complete roster of signals required for myocardial specification is crucial to
the future of cardiac regenerative medicine. Prior studies have implicated the Hedgehog …

Formaldehyde exposure during pregnancy can cause fetal congenital heart disease (CHD).
However, the regulatory mechanism remains unclear. Studies on the biology of long non …

Publisher Summary This chapter discusses the functions and interactions of genes that
subdivide the early mesoderm, orchestrate the specification and initial differentiation of the …

The Drosophila system has proven a powerful tool to help unlock the regulatory processes
that occur during specification and differentiation of the embryonic heart. In this review, we …

Rationale: Normal cardiac physiology requires highly regulated cytosolic Ca2+
concentrations and abnormalities in Ca2+ handling are associated with heart failure. The …

Although hyperactivation of Ras is a common feature of myeloid malignancy, its role in
subverting hematopoiesis is unclear. We have examined the influence of Ras on normal …

Thisbe (Ths) and Pyramus (Pyr), two closely related Drosophila homologues of the
vertebrate fibroblast growth factor (FGF) 8/17/18 subfamily, are ligands for the FGF receptor …