Beclin-1 is the firstly-identified mammalian protein of the autophagy machinery, which
functions as a molecular scaffold for the assembly of PI3KC3 (class III phosphatidylinositol 3 …

Landmark genome-wide association studies (GWAS) identified that mutations in autophagy
genes correlated with inflammatory bowel disease (IBD), a heterogenous disease …

BH3-mimetics represent promising anti-cancer agents in tumors that rely on the anti-
apoptotic function of B-Cell Lymphoma 2 (BCL2) proteins, particularly in leukemia and …

As the most malignant primary brain tumor in adults, a diagnosis of glioblastoma multiforme
(GBM) continues to carry a poor prognosis. GBM is characterized by cytoprotective …

Activation of RET tyrosine kinase plays a critical role in the pathogenesis of various cancers,
including non‐small cell lung cancer, papillary thyroid cancers, multiple endocrine …

Mitochondria are organelles that serve as a central hub for physiological processes in
eukaryotes, including production of ATP, regulation of calcium dependent signaling …

Pediatric low-grade gliomas (PLGGs) comprise a heterogeneous set of low-grade glial and
glioneuronal tumors, collectively representing the most frequent CNS tumors of childhood …

White matter dysplasia (WMD) in preterm infants due to intrauterine inflammation is caused
by excessive apoptosis of oligodendrocyte precursor cells (OPCs). In recent years, studies …

The BCL (B-cell lymphoma) protein family is a diverse group of regulators critically involved
in apoptosis, a tightly controlled process crucial for maintaining tissue homeostasis …

Glioblastoma is the commonest and deadliest primary brain tumor. Glioblastoma is
characterized by significant intra-and inter-tumoral heterogeneity, resistance to treatment …