Combinations of histone post-translational modifications
Histones are essential proteins that package the eukaryotic genome into its physiological
state of nucleosomes, chromatin, and chromosomes. Post-translational modifications (PTMs) …
state of nucleosomes, chromatin, and chromosomes. Post-translational modifications (PTMs) …
Epigenetic causes of overgrowth syndromes
Human overgrowth disorders are characterized by excessive prenatal and/or postnatal
growth of various tissues. These disorders often present with tall stature, macrocephaly …
growth of various tissues. These disorders often present with tall stature, macrocephaly …
Functional roles of bromodomain proteins in cancer
Simple Summary This review provides an in depth analysis of the role of bromodomain-
containing proteins in cancer development. As readers of acetylated lysine on nucleosomal …
containing proteins in cancer development. As readers of acetylated lysine on nucleosomal …
BRPF1-KAT6A/KAT6B complex: molecular structure, biological function and human disease
G Zu, Y Liu, J Cao, B Zhao, H Zhang, L You - Cancers, 2022 - mdpi.com
Simple Summary BRPF1 (also named as BR140) was identified 28 years ago, and it was not
until the past 5 years that its mutations in humans caught increasing attention. Those …
until the past 5 years that its mutations in humans caught increasing attention. Those …
A comprehensive atlas of epigenetic regulators reveals tissue-specific epigenetic regulation patterns
J Wang, A Shi, J Lyu - Epigenetics, 2023 - Taylor & Francis
Epigenetic machinery contributes to gene regulation in eukaryotic species. However, the
machinery including more than 600 epigenetic regulator (ER) genes responsible for …
machinery including more than 600 epigenetic regulator (ER) genes responsible for …
Molecular insights into the recognition of acetylated histone modifications by the BRPF2 bromodomain
HBO1 [HAT bound to the origin recognition complex (ORC)], a member of the MYST family of
histone acetyltransferases (HATs), was initially identified as a binding partner of ORC that …
histone acetyltransferases (HATs), was initially identified as a binding partner of ORC that …
SIN-3 acts in distinct complexes to regulate the germline transcriptional program in Caenorhabditis elegans
The transcriptional co-regulator SIN3 influences gene expression through multiple
interactions that include histone deacetylases. Haploinsufficiency and mutations in SIN3 are …
interactions that include histone deacetylases. Haploinsufficiency and mutations in SIN3 are …
Uncovering the non-histone interactome of the BRPF1 bromodomain using site-specific azide-acetyllysine photochemistry
Bromodomain-PHD finger protein 1 (BRPF1) belongs to the BRPF family of bromodomain-
containing proteins. Bromodomains are exclusive reader modules that recognize and bind …
containing proteins. Bromodomains are exclusive reader modules that recognize and bind …
Insights into the molecular mechanisms of histone code recognition by the BRPF3 bromodomain
Bromodomains are evolutionarily conserved reader modules that recognize acetylated
lysine residues on the histone tails to facilitate gene transcription. The bromodomain and …
lysine residues on the histone tails to facilitate gene transcription. The bromodomain and …
Coordination of di-acetylated histone ligands by the ATAD2 bromodomain
CM Evans, M Phillips, KL Malone, M Tonelli… - International journal of …, 2021 - mdpi.com
The ATPase Family, AAA domain-containing protein 2 (ATAD2) bromodomain (BRD) has a
canonical bromodomain structure consisting of four α-helices. ATAD2 functions as a co …
canonical bromodomain structure consisting of four α-helices. ATAD2 functions as a co …