DNA methylation is of paramount importance for mammalian embryonic development. DNA
methylation has numerous functions: it is implicated in the repression of transposons and …

The DNA methyltransferase (DNMT) family comprises a conserved set of DNA-modifying
enzymes that have a central role in epigenetic gene regulation. Recent studies have shown …

Enzymes that catalyse CpG methylation in DNA, including the DNA methyltransferases 1
(DNMT1), 3A (DNMT3A) and 3B (DNMT3B), are indispensable for mammalian tissue …

Immunological memory is an important evolutionary trait that improves host survival upon
reinfection. Memory is a characteristic recognized within both the innate and adaptive arms …

Mitotic cell division increases tumour mutation burden and copy number load, predictive
markers of the clinical benefit of immunotherapy. Cell division correlates also with genomic …

DNA methylation (DNAme) and histone post-translational modifications (PTMs) have
important roles in transcriptional regulation. Although many reports have characterized the …

Through various pathways of cell death, degradation, and regulated extrusion, partial or
complete genomes of various origins (eg, host cells, fetal cells, and infiltrating viruses and …

Eukaryotic cells compartmentalize their internal milieu in order to achieve specific reactions
in time and space. This organization in distinct compartments is essential to allow …

Experimental modelling of human disorders enables the definition of the cellular and
molecular mechanisms underlying diseases and the development of therapies for treating …

DNA methylation is among the best studied epigenetic modifications and is essential to
mammalian development. Although the methylation status of most CpG dinucleotides in the …