With the increasing risk of invasive and life threating fungal infections, there is now a great
concern regarding the lower discovery rate of antifungal drugs in comparison to …

Aspergillus fumigatus is one of the most ubiquitous of the airborne saprophytic fungi.
Humans and animals constantly inhale numerous conidia of this fungus. The conidia are …

This review concentrates on success stories from the synthesis of approved medicines and
drug candidates using epoxide chemistry in the development of robust and efficient …

Different kinds of mycoses, especially invasive, have become an important public health
problem as their incidence has increased dramatically in the last decades in relation to …

Fungal diseases are an increasing global burden. Fungi are now recognised to kill more
people annually than malaria, whilst in agriculture, fungi threaten crop yields and food …

A series of (2R, 3S)-2-(2, 4-difluorophenyl)-3-(5-{2-[4-aryl-piperazin-1-yl]-ethyl}-tetrazol-2-yl)-
1-[1, 2, 4]-triazol-1-yl-butan-2-ol (11a–n) and (2R, 3S)-2-(2, 4-difluorophenyl)-3-(5-{2-[4-aryl …

Triazoles with fused-heterocycle nuclei were designed and evaluated for their in vitro activity
on the basis of the binding mode of albaconazole using molecular docking, along with SAR …

Heterocyclic rings have long piqued the interest of medicinal chemists. Quinazolinone is a
fused nitrogen‐based heterocyclic moiety. Some of quinazolinone derivatives have …

Although several new antifungal drugs have been licensed in the last 5 years, some patients
remain difficult to treat. The main reasons for this include intrinsic or acquired antifungal …

Background: The use of plants for healing purposes predates recorded history and forms the
origin of much of modern medicine. Many conventional drugs originated from plant sources …