Metformin is a well-known anti-diabetic drug that has been repurposed for several emerging
applications, including as an anti-cancer agent. It boasts the distinct advantages of an …

Objective Use of the frailty index to measure an accumulation of deficits has been proven a
valuable method for identifying elderly people at risk for increased vulnerability, disease …

MYC is a highly pleiotropic transcription factor whose deregulation promotes cancer. In
contrast, we find that Myc haploinsufficient (Myc+/–) mice exhibit increased lifespan. They …

In addition to the anti-diabetic effect of metformin, a growing number of studies have shown
that metformin has some exciting properties, such as anti-oxidative capabilities, anticancer …

Metformin, a first line medication for type II diabetes, initially entered the spotlight as a
promising anti-cancer agent due to epidemiologic reports that found reduced cancer risk …

Metformin, an oral hypoglycemic agent, has been used for decades to treat type 2 diabetes
mellitus. Recent studies indicate that mice treated with metformin live longer and have fewer …

Obesity or a high-fat diet represses the endoribonuclease activity of inositol-requiring
enzyme 1α (IRE1α), a transducer of the unfolded protein response (UPR) in cells under …

Cancer risk reduction using pharmacological means is an attractive modern preventive
approach that supplements the classical behavioural prevention recommendations …

Dysregulated metabolism is a common feature of cancer cells and is considered a hallmark
of cancer. Altered tumor-metabolism confers an adaptive advantage to cancer cells to fulfill …

Aging can be viewed as a quasi-programmed phenomenon driven by the overactivation of
the nutrient-sensing mTOR gerogene. mTOR-driven aging can be triggered or accelerated …