The retina as a window to the brain—from eye research to CNS disorders
A London, I Benhar, M Schwartz - Nature Reviews Neurology, 2013 - nature.com
Philosophers defined the eye as a window to the soul long before scientists addressed this
cliché to determine its scientific basis and clinical relevance. Anatomically and …
cliché to determine its scientific basis and clinical relevance. Anatomically and …
Optical coherence tomography in multiple sclerosis: a systematic review and meta-analysis
A Petzold, JF de Boer, S Schippling… - The Lancet …, 2010 - thelancet.com
Optical coherence tomography (OCT) is a new method that could aid analysis of
neurodegeneration in multiple sclerosis (MS) by capturing thinning of the retinal nerve fibre …
neurodegeneration in multiple sclerosis (MS) by capturing thinning of the retinal nerve fibre …
Optical coherence tomography reflects brain atrophy in multiple sclerosis: a four‐year study
S Saidha, O Al‐Louzi, JN Ratchford… - Annals of …, 2015 - Wiley Online Library
Objective The aim of this work was to determine whether atrophy of specific retinal layers
and brain substructures are associated over time, in order to further validate the utility of …
and brain substructures are associated over time, in order to further validate the utility of …
Vision and vision-related outcome measures in multiple sclerosis
LJ Balcer, DH Miller, SC Reingold, JA Cohen - Brain, 2015 - academic.oup.com
Visual impairment is a key manifestation of multiple sclerosis. Acute optic neuritis is a
common, often presenting manifestation, but visual deficits and structural loss of retinal …
common, often presenting manifestation, but visual deficits and structural loss of retinal …
Primary retinal pathology in multiple sclerosis as detected by optical coherence tomography
Optical coherence tomography studies in multiple sclerosis have primarily focused on
evaluation of the retinal nerve fibre layer. The aetiology of retinal changes in multiple …
evaluation of the retinal nerve fibre layer. The aetiology of retinal changes in multiple …
Optical coherence tomography: a window into the mechanisms of multiple sclerosis
EM Frohman, JG Fujimoto, TC Frohman… - Nature clinical practice …, 2008 - nature.com
The pathophysiology of multiple sclerosis (MS) is characterized by demyelination, which
culminates in a reduction in axonal transmission. Axonal and neuronal degeneration seem …
culminates in a reduction in axonal transmission. Axonal and neuronal degeneration seem …
Relationships between retinal axonal and neuronal measures and global central nervous system pathology in multiple sclerosis
Objective To determine the relationships between conventional and segmentation-derived
optical coherence tomography (OCT) retinal layer thickness measures with intracranial …
optical coherence tomography (OCT) retinal layer thickness measures with intracranial …
Retinal imaging as a source of biomarkers for diagnosis, characterization and prognosis of chronic illness or long-term conditions
TJ MacGillivray, E Trucco, JR Cameron… - The British journal of …, 2014 - academic.oup.com
The black void behind the pupil was optically impenetrable before the invention of the
ophthalmoscope by von Helmholtz over 150 years ago. Advances in retinal imaging and …
ophthalmoscope by von Helmholtz over 150 years ago. Advances in retinal imaging and …
[HTML][HTML] Optical coherence tomography (OCT): imaging the visual pathway as a model for neurodegeneration
Axonal and neuronal degeneration are important features of multiple sclerosis (MS) and
other neurologic disorders that affect the anterior visual pathway. Optical coherence …
other neurologic disorders that affect the anterior visual pathway. Optical coherence …
Retinal nerve fiber layer thinning in dementia associated with Parkinson's disease, dementia with Lewy bodies, and Alzheimer's disease
T Moreno-Ramos, J Benito-León… - Journal of …, 2013 - content.iospress.com
Optical coherence tomography is a simple, high-resolution technique to quantify the
thickness of retinal nerve fiber layer (RNFL). Previous studies have shown that degenerative …
thickness of retinal nerve fiber layer (RNFL). Previous studies have shown that degenerative …