Nucleic acids have been among the first targets for antitumor drugs and antibiotics. With the
unveiling of new biological roles in regulation of gene expression, specific DNA and RNA …

Specific interactions between proteins and DNA are fundamental to many biological
processes. In this review, we provide a revised view of protein-DNA interactions that …

The observed sequence dependence of the mean twist angles in 38B-DNA crystal structures
can be understood in terms of simple geometrical features of the constituent base-pairs …

A cryo-electron microscopy study of supercoiled DNA molecules freely suspended in cryo-
vitrified buffer was combined with Monte Carlo simulations and gel electrophoretic analysis …

▪ Abstract Structural data on protein-DNA complexes provide clues for understanding the
mechanism of protein-DNA recognition. Although the structures of a large number of protein …

▪ Abstract Nearly twenty years after the first high-resolution crystal structures of specific
protein-DNA complexes were determined, the stereo-chemical basis for protein-DNA …

The eubacterial SOS system is a paradigm of cellular DNA damage and repair, and its
activation can contribute to antibiotic resistance,,. Under normal conditions, LexA represses …

An increasing number of transcription factors both from prokaryotic and eukaryotic sources
are found to bend the DNA upon binding to their recognition site. Bending can easily be …

Although DNA is frequently bent and supercoiled in the cell, much of the available
information on DNA structure at the atomistic level is restricted to short linear sequences. We …

We have used nuclear magnetic resonance (NMR) to obtain the structure of an RNA
“kissing” hairpin complex formed between the HIV-2 TAR hairpin loop and a hairpin with a …