Endothelial cells play critical roles in circulatory homeostasis and are also the gateway to
the major organs of the body. Dysfunction, injury, and gene expression profiles of these cells …

Primary liver cancer has become the second most fatal cancer in the world, and its five-year
survival rate is only 10%. Most patients are in the middle and advanced stages at the time of …

Abstract Analysis of off-target editing is an important aspect of the development of safe
nuclease-based genome editing therapeutics. in vivo assessment of nuclease off-target …

Hepatocellular carcinoma (HCC) is now a common cause of cancer death, with no obvious
change in patient survival over the past few years. Although the traditional therapeutic …

CRISPR/Cas9 gene editing has revolutionised biomedical research. The ease of design has
allowed many groups to apply this technology for disease modelling in animals. While the …

Most experimental oncology therapies fail during clinical development despite years of
preclinical testing rationalizing their use. This begs the question of whether the current …

Cholangiocarcinoma (CCA) is a highly aggressive biliary tree malignancy with intrahepatic
and extra-hepatic subtypes that differ in molecular pathogeneses, epidemiology, clinical …

CRISPR/Cas9‐driven cancer modeling studies are based on the disruption of tumor
suppressor genes by small insertions or deletions (indels) that lead to frame‐shift mutations …

Splicing alterations have been shown to be key tumorigenesis drivers. In this study, we
identified a novel spliceosome-related genes (SRGs) signature to predict the overall survival …

The Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR) mediated Cas9
nuclease system has been extensively used for genome editing and gene modification in …