Numerous tissue regeneration paradigms show evident neurological dependence, including
mammalian fingertip, skin, and bone regeneration. The mature skeleton is innervated by an …

Neuropilins (NRPs) are non-tyrosine kinase cell surface glycoproteins expressed in all
vertebrates and widely conserved across species. The two isoforms, such as neuropilin-1 …

Checkpoint blockade immunotherapy established a new paradigm in cancer treatment: for
certain patients curative treatment requires immune reinvigoration. Despite this monumental …

Different types of cell behavior, including growth, motility, and navigation, require actin
proteins to assemble into filaments. Here, we describe a biochemical process that was able …

Abstract Neuropilin 1 (NRP1) is a transmembrane glycoprotein that acts as a co-receptor for
a number of extracellular ligands including class III/IV semaphorins, certain isoforms of …

Semaphorins are newcomers to the growing panoply of immunoregulatory proteins.
Members of this family were originally identified as proteins that provide axonal guidance …

The central nervous system (CNS) is now known to actively communicate with the immune
system to control immune responses both centrally and peripherally. Within the CNS, while …

Semaphorins are a large family of secreted and membrane-bound molecules that were
initially implicated in the development of the nervous system and in axon guidance. More …

Semaphorins are mainly known as guidance signals in development, acting through
receptors called Plexins. However, their role in cancer is rapidly emerging in the regulation …

Treg are immune cells that play a critical role in the regulation of the immune response.
Although the transcription factor Foxp3 is widely accepted as the standard marker of Treg …