[HTML][HTML] Prophylactic and therapeutic roles of oleanolic acid and its derivatives in several diseases

A Sen - World Journal of Clinical Cases, 2020 - ncbi.nlm.nih.gov
Oleanolic acid (OA) and its derivatives are widely found in diverse plants and are naturally
effective pentacyclic triterpenoid compounds with broad prophylactic and therapeutic roles …

Potential molecular targets of oleanolic acid in insulin resistance and underlying oxidative stress: a systematic review

A Fernandez-Aparicio, M Correa-Rodriguez… - Antioxidants, 2022 - mdpi.com
Oleanolic acid (OA) is a natural triterpene widely found in olive leaves that possesses
antioxidant, anti-inflammatory, and insulin-sensitizing properties, among others. These OA …

SIRT1/Nrf2/NF-κB signaling mediates anti-inflammatory and anti-apoptotic activities of oleanolic acid in a mouse model of acute hepatorenal damage

MAI Alqrad, DS El-Agamy, SRM Ibrahim, A Sirwi… - Medicina, 2023 - mdpi.com
Background and objectives: Oleanolic acid (OA) is a penta-cyclic triterpene with diverse
bioactivities such as anticarcinogenic, antiviral, antimicrobial, hepatoprotective, anti …

Skeletal muscle insulin resistance and adipose tissue hypertrophy persist beyond the reshaping of gut microbiota in young rats fed a fructose-rich diet

A Mazzoli, A Di Porzio, C Gatto, R Crescenzo… - The Journal of …, 2023 - Elsevier
To investigate whether short term fructose-rich diet induces changes in the gut microbiota as
well as in skeletal muscle and adipose tissue physiology and verify whether they persist …

Integrating network pharmacology and animal experimental validation to investigate the action mechanism of oleanolic acid in obesity

T Liu, J Wang, Y Tong, L Wu, Y Xie, P He, S Lin… - Journal of Translational …, 2024 - Springer
Background Obesity, a condition associated with the development of widespread
cardiovascular disease, metabolic disorders, and other health complications, has emerged …

Potential protective effect of oleanolic acid on the components of metabolic syndrome: a systematic review

Á Fernández-Aparicio, J Schmidt-RioValle… - Journal of Clinical …, 2019 - mdpi.com
The high prevalence of obesity is a serious public health problem in today's world. Both
obesity and insulin resistance favor the development of metabolic syndrome (MetS), which is …

Oleanolic acid alleviates oxidative stress in Alzheimer's disease by regulating stanniocalcin‐1 and uncoupling protein‐2 signalling

Q Guo, J He, H Zhang, L Yao… - Clinical and Experimental …, 2020 - Wiley Online Library
Oxidative stress is thought to play an important role in the occurrence and development of
Alzheimer's disease (AD) and antioxidants may delay or even treat AD. Oleanolic acid (OA) …

藏茵陈有效成分改善代谢综合征的作用机制研究进展

吴涛, 刘立, 宋红萍 - 中国药房, 2024 - journal.china-pharmacy.com
代谢综合征(MS) 是以肥胖, 糖脂代谢异常以及高血压为主要特征的临床症候群.
藏茵陈是我国藏族民间常用药, 其功效与MS 病机吻合, 对MS 具有对症治疗潜力 …

Rodent models of metabolic disorders: considerations for use in studies of neonatal programming

KG Ibrahim, D Usman, MB Bello, I Malami… - British Journal of …, 2022 - cambridge.org
Epidemiologically, metabolic disorders have garnered much attention, perhaps due to the
predominance of obesity. The early postnatal life represents a critical period for …

Orally administered zingerone does not mitigate alcohol-induced hepatic oxidative stress in growing Sprague Dawley rat pups

B Asiedu, BW Lembede, TT Nyakudya… - Drug and Chemical …, 2023 - Taylor & Francis
Neonatal alcohol exposure (NAE) can induce oxidative stress. We determined whether
zingerone (ZO), a phytochemical with anti-oxidant activity, can mitigate the negative impact …