ATP-binding cassette (ABC) transporters are transmembrane efflux transporters mediating
the extrusion of an array of substrates ranging from amino acids and lipids to xenobiotics …

Membrane protein-mediated resistance is a multidisciplinary challenge that spans fields
such as medicine, agriculture, and environmental science. Understanding its complexity and …

The treatment of relapse or refractory multiple myeloma (RRMM) is still a big challenge in
clinic. Recently, several clinical trials indicated that the XPO1 inhibitor, selinexor could …

The human cytochrome P450 (CYP) enzymes CYP3A4 and CYP3A5 metabolize most drugs
and have high similarities in their structure and substrate preference. Whereas CYP3A4 is …

The rare PEL-negative phenotype is one of the last blood groups with an unknown genetic
basis. By combining whole-exome sequencing and comparative global proteomic …

Membrane palmitoylated proteins (MPPs) are a subfamily of a larger group of multidomain
proteins, namely, membrane-associated guanylate kinases (MAGUKs). The ubiquitous …

The role of ABCC4, an ATP-binding cassette transporter, in the process of platelet formation,
megakaryopoiesis, is unknown. Here, we show that ABCC4 is highly expressed in …

Testis-restricted melanoma antigen (MAGE) proteins are frequently hijacked in cancer and
play a critical role in tumorigenesis. MAGEs assemble with E3 ubiquitin ligases and function …

Background Medulloblastoma is the most frequently occurring malignant brain tumor in
children. Current treatment strategies for medulloblastoma include aggressive surgery …

Background Acute myeloid leukaemia (AML) is a malignant haematological tumour with
high heterogeneity and mortality. A reliable prognostic assessment is critical for treatment …