Glucose metabolism in cardiac hypertrophy and heart failure

DH Tran, ZV Wang - Journal of the American Heart Association, 2019 - Am Heart Assoc
Heart failure is one of the leading causes of death worldwide and has been singled out as
an emerging epidemic. 1, 2 With a 5-year survival rate of 50%, heart failure poses a …

Myocardial fatty acid metabolism in health and disease

GD Lopaschuk, JR Ussher, CDL Folmes… - Physiological …, 2010 - journals.physiology.org
There is a constant high demand for energy to sustain the continuous contractile activity of
the heart, which is met primarily by the β-oxidation of long-chain fatty acids. The control of …

2013 ACCF/AHA guideline for the management of ST-elevation myocardial infarction: a report of the American College of Cardiology Foundation/American Heart …

PT O'Gara, FG Kushner, DD Ascheim, DE Casey… - Journal of the American …, 2013 - jacc.org
1.1. Methodology and Evidence Review The recommendations listed in this document are,
whenever possible, evidence based. The current document constitutes a full revision and …

Effects of glucagon-like peptide-1 in patients with acute myocardial infarction and left ventricular dysfunction after successful reperfusion

LA Nikolaidis, S Mankad, GG Sokos, G Miske, A Shah… - Circulation, 2004 - Am Heart Assoc
Background—Glucose-insulin-potassium infusions are beneficial in uncomplicated patients
with acute myocardial infarction (AMI) but are of unproven efficacy in AMI with left ventricular …

[HTML][HTML] Targeting fatty acid and carbohydrate oxidation—a novel therapeutic intervention in the ischemic and failing heart

JS Jaswal, W Keung, W Wang, JR Ussher… - … et Biophysica Acta (BBA …, 2011 - Elsevier
Cardiac ischemia and its consequences including heart failure, which itself has emerged as
the leading cause of morbidity and mortality in developed countries are accompanied by …

Admission glucose and mortality in elderly patients hospitalized with acute myocardial infarction: implications for patients with and without recognized diabetes

M Kosiborod, SS Rathore, SE Inzucchi, FA Masoudi… - Circulation, 2005 - Am Heart Assoc
Background—The relationship between admission glucose levels and outcomes in older
diabetic and nondiabetic patients with acute myocardial infarction is not well defined …

Glucagon-like peptide-1 infusion improves left ventricular ejection fraction and functional status in patients with chronic heart failure

GG Sokos, LA Nikolaidis, S Mankad, D Elahi… - Journal of cardiac …, 2006 - Elsevier
BACKGROUND: Insulin resistance is present in the setting of congestive heart failure.
Glucagon-like peptide-1 (GLP-1) is a naturally occurring incretin with both insulinotropic and …

[HTML][HTML] Hyperglycemia: a prothrombotic factor?

BA Lemkes, J Hermanides, JH DeVries… - Journal of Thrombosis …, 2010 - Elsevier
Diabetes mellitus is characterized by a high risk of atherothrombotic events. What is more,
venous thrombosis has also been found to occur more frequently in this patient group. This …

Exenatide reduces infarct size and improves cardiac function in a porcine model of ischemia and reperfusion injury

L Timmers, JPS Henriques, DPV de Kleijn… - Journal of the American …, 2009 - jacc.org
Objectives: This study sought to examine whether exenatide is capable of reducing
myocardial infarct size. Background: Exenatide is a glucagon-like peptide (GLP)-1 analogue …

Use of intensive insulin therapy for the management of glycemic control in hospitalized patients: a clinical practice guideline from the American College of Physicians

A Qaseem, LL Humphrey, R Chou, V Snow… - Annals of internal …, 2011 - acpjournals.org
Description: The American College of Physicians (ACP) developed this guideline to present
the evidence for the link between the use of intensive insulin therapy to achieve different …