Patient-derived xenograft (PDX) models, in which tumor tissues from patients are implanted
into immunocompromised or humanized mice, have shown superiority in recapitulating the …

Triple-negative breast cancer (TNBC) is a subset of breast cancer with aggressive
characteristics and few therapeutic options. The lack of an appropriate therapeutic target is a …

Establishing appropriate preclinical models is essential for cancer research. Evidence
suggests that cancer is a highly heterogeneous disease. This follows the growing use of …

Triple-negative breast cancer (TNBC) patients with mesenchymal stem-like (MSL) subtype
have responded poorly to chemotherapy whereas patients with basal-like 1 (BL1) subtype …

Simple Summary Triple-negative breast cancer (TNBC) is the most aggressive subtype of
breast cancer and has a poor prognosis and higher recurrence rate due to ineffective …

The rapid onset of resistance to epidermal growth factor receptor tyrosine kinase inhibitor
(EGFR-TKI) limits its clinical utility in colorectal cancer (CRC) patients, and pan-erb-b2 …

Simple Summary The approval of the two antibody combinations trastuzumab/pertuzumab
and ipilimumab/nivolumab in oncology has paved the way for novel antibody combinations …

Purpose. Sym013 contains six humanized monoclonal antibodies that bind to non-
overlapping epitopes on three human epidermal growth factor receptors (HER1-3) …

Plasmodium falciparum aminoacyl tRNA synthetases (PfaaRSs) are potent antimalarial
targets essential for proteome fidelity and overall parasite survival in every stage of the …

Background Human protein kinases, the key players in phosphoryl signal transduction, have
been actively investigated as drug targets for complex diseases such as cancer, immune …