Spatially resolved mass spectrometry at the single cell: recent innovations in proteomics and metabolomics

MJ Taylor, JK Lukowski… - Journal of the American …, 2021 - ACS Publications
Biological systems are composed of heterogeneous populations of cells that
intercommunicate to form a functional living tissue. Biological function varies greatly across …

Quantitative mass spectrometry imaging of biological systems

D Unsihuay, D Mesa Sanchez… - Annual review of physical …, 2021 - annualreviews.org
Mass spectrometry imaging (MSI) is a powerful, label-free technique that provides detailed
maps of hundreds of molecules in complex samples with high sensitivity and subcellular …

Spatial omics: Navigating to the golden era of cancer research

Y Wu, Y Cheng, X Wang, J Fan… - Clinical and Translational …, 2022 - Wiley Online Library
The idea that tumour microenvironment (TME) is organised in a spatial manner will not
surprise many cancer biologists; however, systematically capturing spatial architecture of …

Electrospray ionization mass spectrometry: a technique to access the information beyond the molecular weight of the analyte

S Banerjee, S Mazumdar - International journal of analytical …, 2012 - Wiley Online Library
The Electrospray Ionization (ESI) is a soft ionization technique extensively used for
production of gas phase ions (without fragmentation) of thermally labile large …

[HTML][HTML] Large-scale lipid analysis with C=C location and sn-position isomer resolving power

W Cao, S Cheng, J Yang, J Feng, W Zhang, Z Li… - Nature …, 2020 - nature.com
Lipids play a pivotal role in biological processes and lipid analysis by mass spectrometry
(MS) has significantly advanced lipidomic studies. While the structure specificity of lipid …

Mass spectrometry‐based plant metabolomics: Metabolite responses to abiotic stress

TF Jorge, JA Rodrigues, C Caldana… - Mass spectrometry …, 2016 - Wiley Online Library
Metabolomics is one omics approach that can be used to acquire comprehensive
information on the composition of a metabolite pool to provide a functional screen of the …

Mass spectrometry imaging under ambient conditions

C Wu, AL Dill, LS Eberlin, RG Cooks… - Mass spectrometry …, 2013 - Wiley Online Library
Mass spectrometry imaging (MSI) has emerged as an important tool in the last decade and it
is beginning to show potential to provide new information in many fields owing to its unique …

Mass spectrometric imaging for biomedical tissue analysis

K Chughtai, RMA Heeren - Chemical reviews, 2010 - ACS Publications
A mass spectrometer is described as the smallest weighing scale ever used in the world. 1
Mass spectrometry (MS) is a unique technique that has an interdisciplinary nature, which …

Development, characterization, and application of paper spray ionization

J Liu, H Wang, NE Manicke, JM Lin, RG Cooks… - Analytical …, 2010 - ACS Publications
Paper spray is developed as a direct sampling ionization method for mass spectrometric
analysis of complex mixtures. Ions of analyte are generated by applying a high voltage to a …

Desorption electrospray ionization mass spectrometry: 20 years

NM Morato, RG Cooks - Accounts of chemical research, 2023 - ACS Publications
Conspectus Mass spectrometry (MS) is one of the most widely used technologies in the
chemical sciences. With applications spanning the monitoring of reaction products, the …