The recombination between immunoglobulin (IG) gene segments determines an individual's
naïve antibody repertoire and, consequently,(auto) antigen recognition. Emerging evidence …

The ability to rearrange the germ-line DNA to generate antibody diversity is an essential
prerequisite for the production of a functional repertoire. While this is essential to prevent …

Despite having several characteristics of naı̈ve B cells, chronic lymphocytic leukemia (CLL)
cells have been shown in some cases to have somatically mutated Ig variable region genes …

To better understand the stage (s) of differentiation reached by B-type chronic lymphocytic
leukemia (B-CLL) cells and to gain insight into the potential role of antigenic stimulation in …

Background The CD19 protein forms a complex with CD21, CD81, and CD225 in the
membrane of mature B cells. Together with the B-cell antigen receptor, this complex signals …

Antibody deficiencies constitute the largest group of symptomatic primary immunodeficiency
diseases. In several patients, mutations in CD19 have been found to underlie disease …

The contribution of proliferation to B lymphocyte homeostasis and antigen responses is
largely unknown. We quantified the replication history of mouse and human B lymphocyte …

In patients with rheumatoid arthritis the synovial membrane of the affected joint is infiltrated
with lymphoid cells which may be arranged in structures resembling germinal centers. We …

In humans, up to 40% of peripheral B cells express CD27 and have hypermutated variable
regions in their Ig genes. The CD27+ B cells are considered to be derived from germinal …

Hepatitis C virus (HCV) is a nonretroviral oncogenic RNA virus, which is frequently
associated with hepatocellular carcinoma (HCC) and B cell lymphoma. We demonstrated …