Structural information of butyrylcholinesterase (BChE) and its variants associated with
several diseases are discussed here. Pure human BChE has been proved safe and effective …

Provides a timely update to a key textbook on human drug metabolism The third edition of
this comprehensive book covers basic concepts of teaching drug metabolism, starting from …

Cocaine abuse is a serious global public health and social problem, and cocaine
detoxification remains a challenge. Benzoylecgonine (BE) is the main toxic metabolite after …

It is particularly challenging to develop a truly effective pharmacotherapy for cocaine use
disorder (CUD) treatment. Accelerating cocaine metabolism via hydrolysis at cocaine …

Cocaine is a widely abused, hepatotoxic drug without an FDA-approved pharmacotherapy
specific for cocaine addiction or overdose. It is recognized as a promising therapeutic …

As well known, cocaine induces stimulant effects and dopamine transporter (DAT) trafficking
to the plasma membrane of dopaminergic neurons. In the present study, we examined …

As new metabolic pathways of cocaine were recently identified, a high performance liquid
chromatography tandem mass spectrometry (LC–MS/MS) method was developed to …

Objective Determine if cocaine use impacts gut permeability, promotes microbial
translocation and immune activation in people living with HIV (PLWH) using effective …

Cocaine blocks dopamine uptake via dopamine transporter (DAT) on plasma membrane of
neuron cells and, as a result, produces the high and induces DAT trafficking to plasma …

Dysregulation of dopamine transporters (DAT) within the dopaminergic system is an
important biomarker of cocaine exposure. Depending on cocaine amount in‐taken, one …