Sex-related responses after traumatic brain injury: Considerations for preclinical modeling

CB Späni, DJ Braun, LJ Van Eldik - Frontiers in neuroendocrinology, 2018 - Elsevier
Traumatic brain injury (TBI) has historically been viewed as a primarily male problem, since
men are more likely to experience a TBI because of more frequent participation in activities …

[HTML][HTML] Neuro-inflammation modulation and post-traumatic brain injury lesions: from bench to bed-side

A Jacquens, EJ Needham, ER Zanier, V Degos… - International journal of …, 2022 - mdpi.com
Head trauma is the most common cause of disability in young adults. Known as a silent
epidemic, it can cause a mosaic of symptoms, whether neurological (sensory–motor …

Effects of voluntary and involuntary exercise on cognitive functions, and VEGF and BDNF levels in adolescent rats

N Uysal, M Kiray, AR Sisman, UM Camsari… - Biotechnic & …, 2015 - Taylor & Francis
Regular treadmill running during adolescence improves learning and memory in rats.
During adolescence, the baseline level of stress is thought to be greater than during other …

[HTML][HTML] Brain trauma, glucocorticoids and neuroinflammation: dangerous liaisons for the hippocampus

IG Komoltsev, NV Gulyaeva - Biomedicines, 2022 - mdpi.com
Glucocorticoid-dependent mechanisms of inflammation-mediated distant hippocampal
damage are discussed with a focus on the consequences of traumatic brain injury. The …

Role and importance of IGF‐1 in traumatic brain injuries

A Mangiola, V Vigo, C Anile, P De Bonis… - BioMed research …, 2015 - Wiley Online Library
It is increasingly affirmed that most of the long‐term consequences of TBI are due to
molecular and cellular changes occurring during the acute phase of the injury and which …

Progesterone treatment following traumatic brain injury in the 11-day-old rat attenuates cognitive deficits and neuronal hyperexcitability in adolescence

D Lengel, JW Huh, JR Barson, R Raghupathi - Experimental neurology, 2020 - Elsevier
Traumatic brain injury (TBI) in children younger than 4 years old results in cognitive and
psychosocial deficits in adolescence and adulthood. At 4 weeks following closed head injury …

The effect of exercise on anxiety-and depression-like behavior of aged rats

O Gokdemir, C Cetinkaya, H Gumus, I Aksu… - Biotechnic & …, 2020 - Taylor & Francis
We investigated the effects of exercise in multiple sessions on anxiety-and depression-like
behavior during aging, and the role of serotonin and serotonin 1A receptors in this process …

[HTML][HTML] Therapeutic effects of progesterone and its metabolites in traumatic brain injury may involve non-classical signaling mechanisms

PS Cooke, MK Nanjappa, Z Yang… - Frontiers in …, 2013 - frontiersin.org
Traumatic brain injury (TBI) is an important and costly medical problem for which no
clinically proven treatment currently exists. Studies in rodents and humans have shown …

Progesterone protects mitochondrial function in a rat model of pediatric traumatic brain injury

CL Robertson, M Saraswati - Journal of bioenergetics and biomembranes, 2015 - Springer
Progesterone has been studied extensively in preclinical models of adult traumatic brain
injury (TBI), and has advanced to clinical trials in adults with TBI. However, there are very …

E2-BSA and G1 exert neuroprotective effects and improve behavioral abnormalities following traumatic brain injury: The role of classic and non-classic estrogen …

L Amirkhosravi, M Khaksari, Z Soltani… - Brain research, 2021 - Elsevier
The role of classical and non-classical estrogen receptors (ERs) in mediating the
neuroprotective effects of this hormone on brain edema and long-term behavioral disorders …