Cerebral blood flow regulation and neurovascular dysfunction in Alzheimer disease

K Kisler, AR Nelson, A Montagne… - Nature Reviews …, 2017 - nature.com
Cerebral blood flow (CBF) regulation is essential for normal brain function. The mammalian
brain has evolved a unique mechanism for CBF control known as neurovascular coupling …

Cerebral microvascular pathology in ageing and neurodegeneration

WR Brown, CR Thore - Neuropathology and applied …, 2011 - Wiley Online Library
WR Brown and CR Thore (2011) Neuropathology and Applied Neurobiology37, 56–74
Cerebral microvascular pathology in ageing and neurodegeneration This review of age …

Vascular dysfunction—the disregarded partner of Alzheimer's disease

MD Sweeney, A Montagne, AP Sagare, DA Nation… - Alzheimer's & …, 2019 - Elsevier
Increasing evidence recognizes Alzheimer's disease (AD) as a multifactorial and
heterogeneous disease with multiple contributors to its pathophysiology, including vascular …

Classification and visualization of Alzheimer's disease using volumetric convolutional neural network and transfer learning

K Oh, YC Chung, KW Kim, WS Kim, IS Oh - Scientific Reports, 2019 - nature.com
Recently, deep-learning-based approaches have been proposed for the classification of
neuroimaging data related to Alzheimer's disease (AD), and significant progress has been …

Microglia–blood vessel interactions: a double-edged sword in brain pathologies

N Dudvarski Stankovic, M Teodorczyk, R Ploen… - Acta …, 2016 - Springer
Microglia are long-living resident immune cells of the brain, which secure a stable chemical
and physical microenvironment necessary for the proper functioning of the central nervous …

Neurovascular mechanisms and blood–brain barrier disorder in Alzheimer's disease

RD Bell, BV Zlokovic - Acta neuropathologica, 2009 - Springer
Vascular dysfunction has a critical role in Alzheimer's disease (AD). Recent data from brain
imaging studies in humans and animal models suggest that cerebrovascular dysfunction …

Multimodal techniques for diagnosis and prognosis of Alzheimer's disease

RJ Perrin, AM Fagan, DM Holtzman - Nature, 2009 - nature.com
Alzheimer's disease affects millions of people around the world. Currently, there are no
treatments that prevent or slow the disease. Like other neurodegenerative diseases …

Identifying and mapping connectivity patterns of brain network hubs in Alzheimer's disease

Z Dai, C Yan, K Li, Z Wang, J Wang, M Cao… - Cerebral …, 2015 - academic.oup.com
Alzheimer's disease (AD) is associated not only with regional gray matter damages, but also
with abnormalities in functional integration between brain regions. Here, we employed …

Blood-brain barrier disruption is an early event that may persist for many years after traumatic brain injury in humans

JR Hay, VE Johnson, AMH Young… - Journal of …, 2015 - academic.oup.com
Traumatic brain injury (TBI) is a risk factor for dementia. Mixed neurodegenerative
pathologies have been described in late survivors of TBI, but the mechanisms driving post …

Permanent, bilateral common carotid artery occlusion in the rat: a model for chronic cerebral hypoperfusion-related neurodegenerative diseases

E Farkas, PGM Luiten, F Bari - Brain research reviews, 2007 - Elsevier
Chronic cerebral hypoperfusion has been associated with cognitive decline in aging and
Alzheimer's disease. Moreover, the pattern of cerebral blood flow in mild cognitive …