B cell and T cell receptor repertoires compose the adaptive immune receptor repertoire
(AIRR) of an individual. The AIRR is a unique collection of antigen-specific receptors that …

Highlights•Immune fitness in health and disease depends notably on the diversity of cellular
repertoires.•Single-cell sequencing is fostering the understanding of clonal diversity of T-cell …

Deep learning algorithms have been utilized to achieve enhanced performance in pattern-
recognition tasks. The ability to learn complex patterns in data has tremendous implications …

Motivation While growing numbers of T cell receptor (TCR) repertoires are being mapped by
high-throughput sequencing, existing methods do not allow for computationally connecting a …

Abs are immune system proteins that recognize noxious molecules for elimination. Their
sequence diversity and binding versatility have made Abs the primary class of …

The adaptive immune system in vertebrates has evolved to recognize non-self antigens,
such as proteins expressed by infectious agents and mutated cancer cells. T cells play an …

The adaptive immune system recognizes antigens via an immense array of antigen-binding
antibodies and T-cell receptors, the immune repertoire. The interrogation of immune …

High-throughput sequencing of B and T cell receptors is routinely being applied in studies of
adaptive immunity. The Adaptive Immune Receptor Repertoire (AIRR) Community was …

Immunotherapies have revolutionized cancer treatment. In particular, immune checkpoint
therapy (ICT) leads to durable responses in some patients with some cancers. However, the …

IgA is the dominant immunoglobulin isotype produced in mammals, largely secreted across
the intestinal mucosal surface. Although induction of IgA has been a hallmark feature of …