Sex-dependent effects of cannabis and cannabinoids: a translational perspective

ZD Cooper, RM Craft - Neuropsychopharmacology, 2018 - nature.com
Recent policy changes have led to significant increases in the use of cannabis for both
medical and recreational purposes. Although men are more likely to endorse past month …

Sex differences and the endocannabinoid system in pain

HL Blanton, RC Barnes, MC McHann, JA Bilbrey… - Pharmacology …, 2021 - Elsevier
Cannabis use has been increasing in recent years, particularly among women, and one of
the most common uses of cannabis for medical purposes is pain relief. Pain conditions and …

Sex differences in addictive disorders

L Fattore, M Melis, P Fadda, W Fratta - Frontiers in neuroendocrinology, 2014 - Elsevier
Gender-dependent differences in the rate of initiation and frequency of misuse of addicting
drugs have been widely described. Yet, men and women also differ in their propensity to …

Sex-dependent effects of in utero cannabinoid exposure on cortical function

A Bara, A Manduca, A Bernabeu, M Borsoi, M Serviado… - Elife, 2018 - elifesciences.org
Cannabinoids can cross the placenta, thus may interfere with fetal endocannabinoid
signaling during neurodevelopment, causing long-lasting deficits. Despite increasing reports …

Mechanisms underlying sex differences in cannabis use

KC Calakos, S Bhatt, DW Foster, KP Cosgrove - Current addiction reports, 2017 - Springer
Abstract Purpose of the Review Cannabis is the most commonly used illicit substance
worldwide. In recent decades, highly concentrated products have flooded the market, and …

Quality of life and a surveillant endocannabinoid system

RA de Melo Reis, AR Isaac, HR Freitas… - Frontiers in …, 2021 - frontiersin.org
The endocannabinoid system (ECS) is an important brain modulatory network. ECS
regulates brain homeostasis throughout development, from progenitor fate decision to neuro …

Sex differences in cannabis withdrawal symptoms among treatment-seeking cannabis users.

ES Herrmann, EM Weerts… - Experimental and clinical …, 2015 - psycnet.apa.org
Over 300,000 individuals enter treatment for cannabis-use disorders (CUDs) in the United
States annually. Cannabis withdrawal is associated with poor CUD-treatment outcomes, but …

Cannabis use, abuse, and withdrawal: Cannabinergic mechanisms, clinical, and preclinical findings

AJ Kesner, DM Lovinger - Journal of neurochemistry, 2021 - Wiley Online Library
Cannabis sativa is the most widely used illicit drug in the world. Its main psychoactive
component is delta‐9‐tetrahydrocannabinol (THC), one of over 100 phytocannabinoid …

Sex‐dependent effects of endocannabinoid modulation of conditioned fear extinction in rats

M Morena, AS Nastase, A Santori… - British Journal of …, 2021 - Wiley Online Library
Background and Purpose Women are twice as likely as men to develop post‐traumatic
stress disorder (PTSD) making the search for biological mechanisms underlying these …

Sex-dependent effects of cannabis-induced analgesia

ZD Cooper, M Haney - Drug and alcohol dependence, 2016 - Elsevier
Background Preclinical studies demonstrate that cannabinoid-mediated antinociceptive
effects vary according to sex; it is unknown if these findings extend to humans. Methods This …