Class A GPCRs: Structure, function, modeling and structure-based ligand design
G protein-coupled receptors (GPCRs), especially the class A, are the most heavily
investigated drug targets in the pharmaceutical industry. Tremendous efforts have been …
investigated drug targets in the pharmaceutical industry. Tremendous efforts have been …
[图书][B] Antimicrobial peptides
DA Phoenix, SR Dennison, F Harris - 2012 - books.google.com
In this text, the small team of expert authors presents the field in a comprehensive and
accessible manner that is well suited for students and junior researchers. The result is a …
accessible manner that is well suited for students and junior researchers. The result is a …
Activation mechanism of the G protein-coupled sweet receptor heterodimer with sweeteners and allosteric agonists
The sweet taste in humans is mediated by the TAS1R2/TAS1R3 G protein-coupled receptor
(GPCR), which belongs to the class C family that also includes the metabotropic glutamate …
(GPCR), which belongs to the class C family that also includes the metabotropic glutamate …
Structure-based discovery and binding site analysis of histamine receptor ligands
R Kiss, GM Keserű - Expert Opinion on Drug Discovery, 2016 - Taylor & Francis
Introduction: The application of structure-based drug discovery in histamine receptor
projects was previously hampered by the lack of experimental structures. The publication of …
projects was previously hampered by the lack of experimental structures. The publication of …
How broadly tuned olfactory receptors equally recognize their agonists. Human OR1G1 as a test case
L Charlier, J Topin, C Ronin, SK Kim… - Cellular and molecular …, 2012 - Springer
The molecular features that dominate the binding mode of agonists by a broadly tuned
olfactory receptor are analyzed through a joint approach combining cell biology, calcium …
olfactory receptor are analyzed through a joint approach combining cell biology, calcium …
Structures and agonist binding sites of bitter taste receptor TAS2R5 complexed with Gi protein and validated against experiment
Bitter taste receptors (TAS2Rs) function in taste perception, but are also expressed in many
extraoral tissues, presenting attractive therapeutic targets. TAS2R5s expressed on human …
extraoral tissues, presenting attractive therapeutic targets. TAS2R5s expressed on human …
Predicted structure of agonist-bound glucagon-like peptide 1 receptor, a class BG protein-coupled receptor
The glucagon-like peptide 1 receptor (GLP1R) is a G protein-coupled receptor (GPCR)
involved in insulin synthesis and regulation; therefore, it is an important drug target for …
involved in insulin synthesis and regulation; therefore, it is an important drug target for …
[HTML][HTML] Predicted structure and cell signaling of TAS2R14 reveal receptor hyper-flexibility for detecting diverse bitter tastes
The 25 human bitter taste receptors (TAS2Rs) are expressed on taste and extra-oral cells
representing an integrated chemosensory system. The archetypal TAS2R14 is activated by> …
representing an integrated chemosensory system. The archetypal TAS2R14 is activated by> …
Predicted structure of fully activated Tas1R3/1R3′ homodimer bound to G protein and natural sugars: Structural insights into G protein activation by a class C sweet …
A Mafi, SK Kim, KC Chou, B Guthrie… - Journal of the …, 2021 - ACS Publications
The Tas1R3 G protein-coupled receptor constitutes the main component of sweet taste
sensory response in humans via forming a heterodimer with Tas1R2 or a homodimer with …
sensory response in humans via forming a heterodimer with Tas1R2 or a homodimer with …
Genetically encoded photo-cross-linkers map the binding site of an allosteric drug on a G protein-coupled receptor
A Grunbeck, T Huber, R Abrol, B Trzaskowski… - ACS chemical …, 2012 - ACS Publications
G protein-coupled receptors (GPCRs) are dynamic membrane proteins that bind
extracellular molecules to transduce signals. Although GPCRs represent the largest class of …
extracellular molecules to transduce signals. Although GPCRs represent the largest class of …