Unnatural amino acids (UAAs) have gained significant attention in protein engineering and
drug development owing to their ability to introduce new chemical functionalities to proteins …

Prodrugs, which remain inert until they are activated under appropriate conditions at the
target site, have emerged as an attractive alternative to drugs that lack selectivity and show …

A series of 2′-deoxyribonucleoside triphosphates (dNTPs) bearing 2-or 4-linked trans-
cyclooctene (TCO) or bicyclononyne (BCN) tethered through a shorter propargylcarbamate …

The ability to site-specifically modify proteins at multiple sites in vivo will enable the study of
protein function in its native environment with unprecedented levels of detail. Here, we …

18F-Labeled [60] fullerene-based molecular spherical nucleic acids (MSNAs), consisting of
a human epidermal growth factor receptor 2 (HER2) mRNA antisense oligonucleotide …

Bioorthogonal chemistry holds great potential to generate difficult‐to‐access protein–protein
conjugate architectures. Current applications are hampered by challenging protein …

Bioorthogonal chemistry has offered an invaluable reactivity-based tool to chemical biology
owing to its exquisite specificity in tagging a diverse set of biomolecules in their native …

The click reaction between a functionalized trans‐cyclooctene (TCO) and a tetrazine (Tz) is
a compelling method for bioorthogonal conjugation in combination with payload releasing …

Despite a range of covalent protein modifications, few techniques exist for quantification of
protein bioconjugation in cells. Here, we describe a novel method for quantifying in cellulo …

Small molecules remain an important category of therapeutic agents. Their binding to
different proteins can lead to both desired and undesired biological effects. Identification of …