Parkinson's disease prevalence is rapidly increasing in an aging global population. With this
increase comes exponentially rising social and economic costs, emphasizing the immediate …

Parkinson's disease (PD) occurs in approximately 1% of the population over 65 years of age
and has become increasingly more common with advances in age. The number of …

Elevated mitochondrial matrix superoxide and/or hydrogen peroxide concentrations drive a
wide range of physiological responses and pathologies. Concentrations of superoxide and …

Essential metals including iron (Fe) and manganese (Mn) with known physiological
functions in human body play an important role in cell homeostasis. Excessive exposure to …

Loss-of-function mutations in parkin is associated with onset of juvenile Parkinson's disease
(PD). Resveratrol is a polyphenolic stilbene with neuroprotective activity. Here, we evaluated …

Parkinson's disease (PD) is a progressive neurodegenerative disorder that arises due to a
complex and variable interplay between elements including age, genetic, and …

Mitochondrial diseases are considered rare genetic disorders characterized by defects in
oxidative phosphorylation (OXPHOS). They can be provoked by mutations in nuclear DNA …

Parkinson's disease (PD) is the second-most common neurodegenerative disorder, whose
physiopathology is still unclear. Moreover, there is an urgent need to discover new …

Mutations in PINK1 and Parkin/PRKN cause the degeneration of dopaminergic neurons in
familial forms of Parkinson's disease but the precise pathogenic mechanisms are unknown …

Introduction Mitochondrial defects have been implicated in Parkinson's disease (PD) since
complex I poisons were found to cause accelerated parkinsonism in young people in the …