It is now well accepted that structures alone cannot explain protein function and biochemical
data. Indeed, dynamics on different timescales play an important role in their function. Many …

Since the discovery of the first penicillin bacterial resistance to β-lactam antibiotics has
spread and evolved promoting new resistances to pathogens. The most common …

β-Lactamases are bacterial enzymes that hydrolyze β-lactam antibiotics. TEM-1 is a
prevalent plasmid-encoded β-lactamase in Gram-negative bacteria that efficiently catalyzes …

Investigation of protein dynamics on the ps-ns and μs-ms timeframes provides detailed
insight into the mechanisms of enzymes and the binding properties of proteins. Nuclear …

β-Lactamase inhibitory protein (BLIP) can effectively inactivate class A β-lactamases, but
with very different degrees of potency. Understanding the different roles of BLIP in class A β …

The rise of multi-drug resistance in bacterial pathogens is one of the grand challenges
facing medical science. A major concern is the speed of development of β-lactamase …

Overwhelming evidence now illustrates the defining role of atomic-scale protein flexibility in
biological events such as allostery, cell signaling, and enzyme catalysis. Over the years …

Modern biological sciences are becoming more and more multidisciplinary. At the same
time, theoretical and computational approaches gain in reliability and their field of …

Proteins are dynamic systems, and understanding dynamics is critical for fully understanding
protein function. Therefore, the question of whether laboratory engineering has an impact on …

TEM family of enzymes is one of the most commonly encountered β-lactamases groups with
different catalytic capabilities against various antibiotics. Despite the studies investigating …