Persistent coxsackievirus B infection and pathogenesis of type 1 diabetes mellitus

MP Nekoua, EK Alidjinou, D Hober - Nature Reviews Endocrinology, 2022 - nature.com
Enteroviruses are believed to trigger or accelerate islet autoimmunity in genetically
susceptible individuals, thereby resulting in loss of functional insulin-producing β-cells and …

Enteroviruses and type 1 diabetes: multiple mechanisms and factors?

RE Lloyd, M Tamhankar… - Annual review of medicine, 2022 - annualreviews.org
Type 1 diabetes (T1D) is a chronic autoimmune disease characterized by insulin deficiency
and resultant hyperglycemia. Complex interactions of genetic and environmental factors …

Pathogenesis of type 1 diabetes: established facts and new insights

A Zajec, K Trebušak Podkrajšek, T Tesovnik, R Šket… - Genes, 2022 - mdpi.com
Type 1 diabetes (T1D) is an autoimmune disease characterized by the T-cell-mediated
destruction of insulin-producing β-cells in pancreatic islets. It generally occurs in genetically …

Coxsackievirus and type 1 diabetes: diabetogenic mechanisms and implications for prevention

A Carré, F Vecchio, M Flodström-Tullberg… - Endocrine …, 2023 - academic.oup.com
The evidence for an association between coxsackievirus B (CVB) infection, pancreatic islet
autoimmunity, and clinical type 1 diabetes is increasing. Results from prospective cohorts …

Viral conjunctivitis

T Muto, S Imaizumi, K Kamoi - Viruses, 2023 - mdpi.com
Viruses account for 80% of all cases of acute conjunctivitis and adenovirus; enterovirus and
herpes virus are the common causative agents. In general, viral conjunctivitis spreads …

Viruses and type 1 diabetes: from enteroviruses to the virome

SR Isaacs, DB Foskett, AJ Maxwell, EJ Ward… - Microorganisms, 2021 - mdpi.com
For over a century, viruses have left a long trail of evidence implicating them as frequent
suspects in the development of type 1 diabetes. Through vigorous interrogation of viral …

Coxsackievirus B3 infects and disrupts human induced-pluripotent stem cell derived brain-like endothelial cells

J Mamana, GM Humber, ER Espinal, S Seo… - Frontiers in Cellular …, 2023 - frontiersin.org
Coxsackievirus B3 (CVB3) is a significant human pathogen that is commonly found
worldwide. CVB3 among other enteroviruses, are the leading causes of aseptic meningo …

Extracellular vesicles regulated by viruses and antiviral strategies

L Yang, J Li, S Li, W Dang, S Xin, S Long… - Frontiers in cell and …, 2021 - frontiersin.org
Extracellular vesicles (EVs), consisting of exosomes, micro-vesicles, and other vesicles,
mainly originate from the multi-vesicular body (MVB) pathway or plasma membrane. EVs are …

Macrophages can transmit coxsackievirus B4 to pancreatic cells and can impair these cells

I Vergez, MP Nekoua, G Arbrandt… - Journal of Medical …, 2024 - Wiley Online Library
Macrophages are suspected to be involved in the pathogenesis of type 1 diabetes. The role
of macrophages in the transmission of coxsackievirus B4 (CVB4) to pancreatic cells and in …

Picornavirus security proteins promote the release of extracellular vesicle enclosed viruses via the modulation of host kinases

KAY Defourny, X Pei, FJM van Kuppeveld… - PLoS …, 2024 - journals.plos.org
The discovery that extracellular vesicles (EVs) serve as carriers of virus particles calls for a
reevaluation of the release strategies of non-enveloped viruses. Little is currently known …