During the last 50 years, novel biomaterials and tissue engineering techniques have been
investigated to produce alternative vascular substitutes that recapitulate the unique elastic …

Since the emergence of regenerative medicine and tissue engineering more than half a
century ago, one obstacle has persisted: the in vitro creation of large-scale vascular tissue (> …

Cardiovascular diseases (CVDs) account for the 31% of total death per year, making them
the first cause of death in the world. Atherosclerosis is at the root of the most life-threatening …

Despite the efforts devoted to drug discovery and development, the number of new drug
approvals have been decreasing. Specifically, cardiovascular developments have been …

One of the tightest bottlenecks in vascular tissue engineering (vTE) is the lack of strength
and elasticity of engineered vascular wall models caused by limited elastic fiber deposition …

The clinical demand for tissue-engineered vascular grafts is still rising, and there are many
challenges that need to be overcome, in particular, to obtain functional small-diameter grafts …

Varying physico-chemical properties of synthetic hydrogels and introducing additives can
induce a cell interactive response of hydrogels. Hydrogels were developed based on …

Vascular tissue engineering combines cells with scaffold materials in vitro aiming the
development of physiologically relevant vascular models. For natural scaffolds such as …

The vascular smooth muscle is vital for regulating blood pressure and maintaining
cardiovascular health, and the resident smooth muscle cells (SMCs) in blood vessel walls …

Cardiovascular diseases remain a leading cause of mortality globally, with atherosclerosis
representing a significant pathological means, often leading to myocardial infarction …