Both Alzheimer's disease (AD) and Type 2 diabetes mellitus (T2DM) share the presence of
systemic and neuro-inflammation, enhanced production and accumulation of β-amyloid …

Small-molecule natural products (NPs) have a long and successful track record of providing
first-in-class drugs and pharmacophore (scaffolds) in all therapeutic areas, serving as a …

In vitro anticholinesterase activities of eight commercially available terpenoid constituents of
Salvia lavandulaefolia have been investigated. These included 1, 8-cineole, camphor, α …

Rivastigmine, a carbamate inhibitor of acetylcholinesterase, is already in use for treatment of
Alzheimer's disease under the trade name of Exelon. Rivastigmine carbamylates Torpedo …

S. fruticosa and S. officinalis var. purpurea was evident. IC50 values decreased from
0.15±0.007 and 0.14±0.007 mg/mL after 5 min to 0.035±0.016 and 0.06±0.018 mg/mL after …

The 3D structure of a complex of the anti‐Alzheimer drug galanthamine with Torpedo
californica acetylcholinesterase is reported. Galanthamine, a tertiary alkaloid extracted from …

Hysteresis loops are phenomena that sometimes are encountered in the analysis of
pharmacokinetic and pharmacodynamic relationships spanning from pre-clinical to clinical …

The structure of Torpedo californica acetylcholinesterase is examined in complex with
several inhibitors that are either in use or under development for treating Alzheimer's …

Alzheimer's disease (AD) is the most common form of dementia, which is one of the four
leading causes of death in developed nations. Until date the only symptomatic treatment for …

Alzheimer's disease (AD), the most common form of dementia, is a degenerative and
progressive neurological disorder characterized by deficit in the cholinergic transmission …