A substantial body of work within the last decade has demonstrated that there is a variety of
oscillatory phenomena that occur in the basal ganglia and in associated regions of the …

The external globus pallidus (GP e) of the basal ganglia is in a unique and powerful position
to influence processing of motor information by virtue of its widespread projections to all …

Neural circuits of the basal ganglia are critical for motor planning and action selection,,. Two
parallel basal ganglia pathways have been described, and have been proposed to exert …

Why dopamine-containing neurons of the brain's substantia nigra pars compacta die in
Parkinson's disease has been an enduring mystery. Our studies suggest that the unusual …

Studies in dopamine-depleted rats indicate that the external globus pallidus (GPe) contains
two main types of GABAergic projection cell; so-called “prototypic” and “arkypallidal” …

Inappropriately synchronized beta (β) oscillations (15–30 Hz) in the subthalamic nucleus
(STN) accompany movement difficulties in idiopathic Parkinson's disease (PD). The cellular …

The dynamical properties of cortico-basal ganglia (CBG) circuits are dramatically altered
following the loss of dopamine in Parkinson's disease (PD). The neural circuit dysfunctions …

The basal ganglia (BG) have long been implicated in both motor function and dysfunction. It
has been proposed that the BG form a centralized action selection circuit, resolving conflict …

Functional connectivity between the prefrontal cortex (PFC) and striatum (STR) is thought
critical for cognition and has been linked to conditions like autism and schizophrenia. We …

Several selective antagonists for adenosine A2A receptors (A2AR) are currently under
evaluation in clinical trials (phases I to III) to treat Parkinson's disease, and they will probably …