Abstract Three-dimensional (3D) cell culture has tremendous advantages to closely mimic
the in vivo architecture and microenvironment of healthy tissue and organs, as well as of …

Many multicellular systems problems can only be understood by studying how cells move,
grow, divide, interact, and die. Tissue-scale dynamics emerge from systems of many …

A decade after the term developmental engineering (DE) was coined to indicate the use of
developmental processes as blueprints for the design and development of engineered living …

Mathematical modeling provides the predictive ability to understand the metabolic
reprogramming and complex pathways that mediate cancer cells' proliferation. We present a …

Cell sorting, whereby a heterogeneous cell mixture organizes into distinct tissues, is a
fundamental patterning process in development. Hydra is a powerful model system for …

Cancer is a disease of cellular regulation, often initiated by genetic mutation within cells, and
leading to a heterogeneous cell population within tissues. In the competition for nutrients …

Recent years have seen a tremendous growth of interest in understanding the role that the
adaptive immune system could play in interdicting tumor progression. In this context, it has …

Metastasis, the leading cause of death in cancer patients, arises when cancer cells
disseminate from a primary solid tumour to distant organs. Growth and invasion of the solid …

Synthetic development is a nascent field of research that uses the tools of synthetic biology
to design genetic programs directing cellular patterning and morphogenesis in higher …

Cellular Potts models are broadly applied across developmental biology and cancer
research. We overcome limitations of the traditional approach, which reinterprets a modified …