Functional and biomimetic materials for engineering of the three-dimensional cell microenvironment
The cell microenvironment has emerged as a key determinant of cell behavior and function
in development, physiology, and pathophysiology. The extracellular matrix (ECM) within the …
in development, physiology, and pathophysiology. The extracellular matrix (ECM) within the …
Non-viral vectors for gene-based therapy
Gene-based therapy is the intentional modulation of gene expression in specific cells to treat
pathological conditions. This modulation is accomplished by introducing exogenous nucleic …
pathological conditions. This modulation is accomplished by introducing exogenous nucleic …
Nanogels: An overview of properties, biomedical applications and obstacles to clinical translation
Nanogels have emerged as a versatile hydrophilic platform for encapsulation of guest
molecules with a capability to respond to external stimuli that can be used for a multitude of …
molecules with a capability to respond to external stimuli that can be used for a multitude of …
Delivery materials for siRNA therapeutics
RNA interference (RNAi) has broad potential as a therapeutic to reversibly silence any gene.
To achieve the clinical potential of RNAi, delivery materials are required to transport short …
To achieve the clinical potential of RNAi, delivery materials are required to transport short …
Nonviral cancer gene therapy: delivery cascade and vector nanoproperty integration
Gene therapy represents a promising cancer treatment featuring high efficacy and limited
side effects, but it is stymied by a lack of safe and efficient gene-delivery vectors. Cationic …
side effects, but it is stymied by a lack of safe and efficient gene-delivery vectors. Cationic …
Recent progress in development of siRNA delivery vehicles for cancer therapy
Recent progress in RNA biology has broadened the scope of therapeutic targets of RNA
drugs for cancer therapy. However, RNA drugs, typically small interfering RNAs (siRNAs) …
drugs for cancer therapy. However, RNA drugs, typically small interfering RNAs (siRNAs) …
Clinical experiences with systemically administered siRNA-based therapeutics in cancer
JE Zuckerman, ME Davis - Nature reviews Drug discovery, 2015 - nature.com
Small interfering RNA (siRNA)-based therapies are emerging as a promising new
anticancer approach, and a small number of Phase I clinical trials involving patients with …
anticancer approach, and a small number of Phase I clinical trials involving patients with …
Organ-on-a-chip platforms for studying drug delivery systems
Novel microfluidic tools allow new ways to manufacture and test drug delivery systems.
Organ-on-a-chip systems—microscale recapitulations of complex organ functions—promise …
Organ-on-a-chip systems—microscale recapitulations of complex organ functions—promise …
Absorption, distribution, metabolism, and excretion of nanocarriers in vivo and their influences
A Zhang, K Meng, Y Liu, Y Pan, W Qu, D Chen… - Advances in Colloid and …, 2020 - Elsevier
As one of the most promising and effective delivery systems for targeted controlled-release
drugs, nanocarriers (NCs) have been widely studied. Although the development of …
drugs, nanocarriers (NCs) have been widely studied. Although the development of …
Balancing Cationic and Hydrophobic Content of PEGylated siRNA Polyplexes Enhances Endosome Escape, Stability, Blood Circulation Time, and Bioactivity in Vivo
A family of pH-responsive diblock polymers composed of poly [(ethylene glycol)-b-[(2-
(dimethylamino) ethyl methacrylate)-co-(butyl methacrylate)], PEG-(DMAEMA-co-BMA), was …
(dimethylamino) ethyl methacrylate)-co-(butyl methacrylate)], PEG-(DMAEMA-co-BMA), was …