Phosphatases and kinases contribute to the regulation of protein phosphorylation
homeostasis in the cell. Phosphorylation is a key post‐translational modification underlying …

Deciphering the many interactions that occur between a virus and host cell over the course
of infection is paramount to understanding mechanisms of pathogenesis and to the future …

A major objective of systems biology is to organize molecular interactions as networks and
to characterize information flow within networks. We describe a computational framework to …

RNA interference (RNAi) represents a powerful method to systematically study loss-of-
function phenotypes on a large scale with a wide variety of biological assays, constituting a …

Abstract Gene3D http://gene3d. biochem. ucl. ac. uk is a comprehensive database of protein
domain assignments for sequences from the major sequence databases. Domains are …

Nonreference sequences (NRSs) are DNA sequences present in global populations but
absent in the current human reference genome. However, the extent and functional …

Adeno-associated viruses (AAVs) display a highly conserved NGR motif on the capsid
surface. Earlier studies have established this tripeptide motif as being essential for integrin …

Targeted therapies have been used to combat many tumor types; however, few have
effectively improved the overall survival in women with epithelial ovarian cancer, begging for …

Synthetic lethality occurs when co-occurrence of two genetic events is unfavorable for the
survival of the cell or organism. The conventional approach of high throughput screening of …

Advances in high-throughput, genome-wide profiling technologies have allowed for an
unprecedented view of the cancer genome landscape. Specifically, high-density microarrays …