Autophagy in the physiological endometrium and cancer

L Devis-Jauregui, N Eritja, ML Davis, X Matias-Guiu… - Autophagy, 2021 - Taylor & Francis
Autophagy is a highly conserved catabolic process and a major cellular pathway for the
degradation of long-lived proteins and cytoplasmic organelles. An increasing body of …

Molecular mechanisms underlying the anticancer activities of licorice flavonoids

Z Zhang, L Yang, J Hou, S Tian, Y Liu - Journal of Ethnopharmacology, 2021 - Elsevier
Ethnopharmacological relevance Licorice has been commonly used in traditional Chinese
medicine for treatment of gastric, liver, and respiratory disease conditions for more than two …

Isoliquiritigenin ameliorates acute pancreatitis in mice via inhibition of oxidative stress and modulation of the Nrf2/HO‐1 pathway

X Liu, Q Zhu, M Zhang, T Yin, R Xu… - Oxidative medicine …, 2018 - Wiley Online Library
Oxidative stress plays a crucial role in the pathogenesis of acute pancreatitis (AP).
Isoliquiritigenin (ISL) is a flavonoid monomer with confirmed antioxidant activity. However …

Perspectives on the Role of Isoliquiritigenin in Cancer

KL Wang, YC Yu, SM Hsia - Cancers, 2021 - mdpi.com
Simple Summary Isoliquiritigenin (ISL), a natural bioactive compound with a chalcone
structure, demonstrates high antitumor efficacy. This review presents a summary of the latest …

MicroRNA-mediated autophagy regulation in cancer therapy: the role in chemoresistance/chemosensitivity

M Ashrafizadeh, A Zarrabi, S Orouei… - European Journal of …, 2021 - Elsevier
Chemoresistance has doubled the effort needed to reach an effective treatment for cancer.
Now, scientists should consider molecular pathways and mechanisms involved in …

Isoliquiritigenin triggers developmental toxicity and oxidative stress–mediated apoptosis in zebrafish embryos/larvae via Nrf2-HO1/JNK-ERK/mitochondrion pathway

Z Song, Y Zhang, H Zhang, RS Rajendran, R Wang… - Chemosphere, 2020 - Elsevier
Isoliquiritigenin (ISL) is an emerging natural flavonoid found in the roots of licorice, exhibits
antioxidant, anti-cancer, anti-inflammatory, anti-allergic, cardioprotective, hepatoprotective …

A review: the anti-inflammatory, anticancer and antibacterial properties of four kinds of licorice flavonoids isolated from licorice

ZF Wang, J Liu, YA Yang, HL Zhu - Current Medicinal Chemistry, 2020 - ingentaconnect.com
Plants have always been an important source of medicines for humans, and licorice is a very
significant herb in the development of humans. As a traditional herb, it is widely cultivated in …

Molecular mechanisms of antiproliferative effects of natural chalcones

R Michalkova, L Mirossay, M Gazdova, M Kello… - Cancers, 2021 - mdpi.com
Simple Summary Despite the important progress in cancer treatment in the past decades,
the mortality rates in some types of cancer have not significantly decreased. Therefore, the …

Antineoplastic activity of isoliquiritigenin, a chalcone compound, in androgen-independent human prostate cancer cells linked to G2/M cell cycle arrest and cell …

B Zhang, Y Lai, Y Li, N Shu, Z Wang, Y Wang… - European Journal of …, 2018 - Elsevier
Isoliquiritigenin is a natural chalcone derived from Glycyrrhiza, which has been reported to
have anti-tumor activity in recent years. Here, we investigate the anticancer efficacy and …

Isoliquiritigenin inhibits cigarette smoke-induced COPD by attenuating inflammation and oxidative stress via the regulation of the Nrf2 and NF-κB signaling pathways

D Yu, X Liu, G Zhang, Z Ming, T Wang - Frontiers in pharmacology, 2018 - frontiersin.org
Chronic obstructive pulmonary disease (COPD) is the major leading cause of disease with
high-mortality worldwide. Cigarette smoke (CS) is a major factor for COPD. CS causes …