During division, eukaryotic cells undergo a dramatic, complex and coordinated remodelling
of their cytoskeleton and membranes. For cell division to occur, chromosomes must be …

As a compartment border, the nuclear envelope (NE) needs to serve as both a protective
membrane shell for the genome and a versatile communication interface between the …

Lipid composition determines organelle identity; however, whether the lipid composition of
the inner nuclear membrane (INM) domain of the ER contributes to its identity is not known …

The endoplasmic reticulum (ER) is an interconnected network of tubular and planar
membranes that supports the synthesis and export of proteins, carbohydrates and lipids …

Akt/PKB is a key master regulator of a wide range of physiological functions including
metabolism, proliferation, survival, growth, angiogenesis and migration and invasion. The …

The cell nucleus is best known as the container of the genome. Its envelope provides a
barrier for passive macromolecule diffusion, which enhances the control of gene expression …

Eukaryotes characteristically organize their genome in a separate compartment, the
nucleus, which is surrounded by the nuclear envelope as a barrier. Ruptures of the nuclear …

The intermediate filament proteins, A-and B-type lamins, form the nuclear lamina scaffold
adjacent to the inner nuclear membrane. B-type lamins confer elasticity, while A-type lamins …

Nuclear lamins form the major structural elements that comprise the nuclear lamina. Loss of
nuclear structural integrity has been implicated as a key factor in the lamin A/C gene …

The preparation of eukaryotic cells for division requires an extensive cellular reorganization,
affecting cytoskeletal elements, chromatin, and organelles. These drastic changes in cellular …