Protein methyl transferases play critical roles in numerous regulatory pathways that underlie
cancer development, progression and therapy-response. Here we discuss the function of …

Metacaspases are cysteine-dependent proteases found in protozoa, fungi and plants and
are distantly related to metazoan caspases. Although metacaspases share structural …

Although emerging cell-or animal-based evidence supports the relationship between SND1
and cancers, no pan-cancer analysis is available. We thus first explored the potential …

N 6-methyladenosine (m6A) is the most abundant internal RNA modification of cellular
mRNAs. m6A is recognised by YTH domain-containing proteins, which selectively bind to …

A cluster of miR‐221/222 is a key player in vascular biology through exhibiting its effects on
vascular smooth muscle cells (VSMCs) and endothelial cells (ECs). These miRNAs …

Resistance against conventional chemotherapeutic agents is one of the main reasons for
tumor relapse and poor clinical outcomes in cancer patients. Various mechanisms are …

Arginine methylation is a common posttranslational modification (PTM) that alters roughly
0.5% of all arginine residues in the cells. There are three types of arginine methylation …

There is virtually no effective treatment for advanced hepatocellular carcinoma (HCC) and
novel targets need to be identified to develop effective treatment. We recently documented …

Programmed cell death (PCD) is executed by proteases, which cleave diverse proteins thus
modulating their biochemical and cellular functions. Proteases of the caspase family and …

Abstract Tudor Staphylococcal Nuclease (TSN or Tudor-SN; also known as SND1) is an
evolutionarily conserved protein involved in the transcriptional and posttranscriptional …