The unique immunological and microbial aspects of pregnancy

G Mor, P Aldo, AB Alvero - Nature Reviews Immunology, 2017 - nature.com
The comparison of the immunological state of pregnancy to an immunosuppressed host–
graft model continues to lead research and clinical practice to ill-defined approaches. This …

The multifaceted actions of leukaemia inhibitory factor in mediating uterine receptivity and embryo implantation

GX Rosario, CL Stewart - American Journal of Reproductive …, 2016 - Wiley Online Library
Embryo implantation is mediated by the combined actions of the ovarian hormones E2 and
P4 on the uterus. In addition, the pro‐inflammatory cytokine, leukaemia inhibitory factor (LIF) …

Curcumin abates hypoxia-induced oxidative stress based-ER stress-mediated cell death in mouse hippocampal cells (HT22) by controlling Prdx6 and NF-κB …

B Chhunchha, N Fatma, E Kubo… - … of Physiology-Cell …, 2013 - journals.physiology.org
Oxidative stress and endoplasmic reticulum (ER) stress are emerging as crucial events in
the etiopathology of many neurodegenerative diseases. While the neuroprotective …

2D-and 3D-cultures of human trabecular meshwork cells: A preliminary assessment of an in vitro model for glaucoma study

S Vernazza, S Tirendi, S Scarfì, M Passalacqua… - PLoS …, 2019 - journals.plos.org
A physiologically relevant in vitro human-based model could be the 'gold standard'to clarify
the pathological steps involved in glaucoma onset. In this regard, human 3D cultures may …

Alpha-herpesvirus thymidine kinase genes mediate viral virulence and are potential therapeutic targets

Y Xie, L Wu, M Wang, A Cheng, Q Yang, Y Wu… - Frontiers in …, 2019 - frontiersin.org
Alpha-herpesvirus thymidine kinase (TK) genes are virulence-related genes and are
nonessential for viral replication; they are often preferred target genes for the construction of …

The regulation of uterine function during parturition: an update and recent advances

M Ilicic, T Zakar, JW Paul - Reproductive Sciences, 2020 - Springer
Successful pregnancy necessitates that the uterus is maintained in a relaxed, quiescent
state for the majority of pregnancy, before being transformed to a contractile and excitable …

Global gene expression analysis in human uterine epithelial cells defines new targets of glucocorticoid and estradiol antagonism

S Whirledge, X Xu, JA Cidlowski - Biology of reproduction, 2013 - academic.oup.com
In preparation for embryo implantation and pregnancy, the uterine epithelium undergoes a
genomic and biological transition that mediates adhesion and invasion of the blastocyst …

Smac mimetics as novel promising modulators of apoptosis in the treatment of breast cancer

A Nikkhoo, N Rostami… - Journal of Cellular …, 2019 - Wiley Online Library
Breast cancer is the most prevalent cancer in women. Despite improvements in treatment,
the rate of breast cancer‐related deaths is still high, and this issue needs further, accurate …

Activation and cleavage of SASH1 by caspase-3 mediates an apoptotic response

JT Burgess, E Bolderson, MN Adams, AM Baird… - Cell death & …, 2016 - nature.com
Apoptosis is a highly regulated cellular process that functions to remove undesired cells
from multicellular organisms. This pathway is often disrupted in cancer, providing tumours …

A pathogenic tau fragment compromises microtubules, disrupts insulin signaling and induces the unfolded protein response

T Guo, D Dakkak, T Rodriguez-Martin, W Noble… - Acta Neuropathologica …, 2019 - Springer
Human tauopathies including Alzheimer's disease, progressive supranuclear palsy and
related disorders, are characterized by deposition of pathological forms of tau, synaptic …