Pathophysiology and treatment of memory dysfunction after traumatic brain injury

R Paterno, KA Folweiler, AS Cohen - Current neurology and neuroscience …, 2017 - Springer
Memory is fundamental to everyday life, and cognitive impairments resulting from traumatic
brain injury (TBI) have devastating effects on TBI survivors. A contributing component to …

Mammalian target of rapamycin (mTOR) signaling pathway and traumatic brain injury: A novel insight into targeted therapy

A Movahedpour, O Vakili, M Khalifeh… - Cell biochemistry …, 2022 - Wiley Online Library
Traumatic brain injury (TBI) is one of the most concerning health issues in which the normal
brain function may be disrupted as a result of a blow, bump, or jolt to the head. Loss of …

Neurotransmitter changes after traumatic brain injury: an update for new treatment strategies

JL McGuire, LB Ngwenya, RE McCullumsmith - Molecular Psychiatry, 2019 - nature.com
Traumatic brain injury (TBI) is a pervasive problem in the United States and worldwide, as
the number of diagnosed individuals is increasing yearly and there are no efficacious …

Mechanistic and therapeutic relationships of traumatic brain injury and γ-amino-butyric acid (GABA)

JM Witkin, H Shafique, JL Smith, AM Marini… - Pharmacology & …, 2024 - Elsevier
Traumatic brain injury is a highly prevalent medical condition for which no medications
specific for the prophylaxis or treatment of the condition as a whole exist. The spectrum of …

Adult born dentate granule cell mediated upregulation of feedback inhibition in a mouse model of traumatic brain injury

YJ Kang, SH Lee, JA Boychuk, CR Butler… - Journal of …, 2022 - Soc Neuroscience
Post-traumatic epilepsy (PTE) and behavioral comorbidities frequently develop after
traumatic brain injury (TBI). Aberrant neurogenesis of dentate granule cells (DGCs) after TBI …

Traumatic brain injury broadly affects GABAergic signaling in dentate gyrus granule cells

AP Becerra, AF Logsdon, WA Banks, CB Ransom - Eneuro, 2021 - eneuro.org
Traumatic brain injury (TBI) causes cellular and molecular alterations that contribute to
neuropsychiatric disease and epilepsy. GABAergic dysfunction figures prominently in the …

[HTML][HTML] Hypocretinergic and cholinergic contributions to sleep-wake disturbances in a mouse model of traumatic brain injury

HE Thomasy, HY Febinger, KM Ringgold… - Neurobiology of Sleep …, 2017 - Elsevier
Disorders of sleep and wakefulness occur in the majority of individuals who have
experienced traumatic brain injury (TBI), with increased sleep need and excessive daytime …

Effects of altered tau expression on dentate granule cell excitability in mice

RA Cloyd, J Koren III, JF Abisambra, BN Smith - Experimental neurology, 2021 - Elsevier
Tauopathies, including Alzheimer's disease, are characterized by progressive accumulation
of hyperphosphorylated and pathologic tau protein in association with onset of cognitive and …

Differential effects of rapamycin treatment on tonic and phasic GABAergic inhibition in dentate granule cells after focal brain injury in mice

CR Butler, JA Boychuk, BN Smith - Experimental neurology, 2016 - Elsevier
The cascade of events leading to post-traumatic epilepsy (PTE) after traumatic brain injury
(TBI) remains unclear. Altered inhibition in the hippocampal formation and dentate gyrus is a …

[HTML][HTML] Blockade of TRPC channels limits cholinergic-driven hyperexcitability and seizure susceptibility after traumatic brain injury

CM Carver, HR DeWitt, AP Stoja… - Frontiers in …, 2021 - frontiersin.org
We investigated the contribution of excitatory transient receptor potential canonical (TRPC)
cation channels to posttraumatic hyperexcitability in the brain 7 days following controlled …