The thin and thick filaments of muscle sarcomeres are interconnected by the giant protein
titin, which is a scaffolding filament, signaling platform, and provider of passive tension and …

The fundamental basis of muscle contraction 'the sliding filament model'(;) and the 'swinging,
tilting crossbridge-sliding filament mechanism'(;) nucleated a field of research that has …

The super-relaxed (SRX) state of myosin was only recently reported in striated muscle. It is
characterised by a sub-population of myosin heads with a highly inhibited rate of ATP …

Contraction of striated muscles is initiated by an increase in cytosolic Ca2+ concentration,
which is regulated by tropomyosin and troponin acting on actin filaments at the sarcomere …

The formulation by Starling of The Law of the Heart states that 'the [mechanical] energy of
contraction, however measured, is a function of the length of the muscle fibre'. Starling later …

Recreating the beating heart in the laboratory continues to be a formidable bioengineering
challenge. The fundamental feature of the heart is its pumping action, requiring considerable …

The Frank-Starling law and Anrep effect describe two intrinsic mechanisms that regulate
contraction force in the heart. Based on recent advancements and the historical literature …

Sarcomeric contraction in cardiomyocytes serves as the basis for the heart's pump functions
in mammals. Although it plays a critical role in the circulatory system, myocardial sarcomere …

The history of muscle physiology is a wonderful lesson in 'the scientific method'; our
functional hypotheses have been limited by our ability to decipher (observe) muscle …

The contractile units of striated muscle, the sarcomeres, comprise the thick (myosin) and thin
(actin) filaments mediating active contraction and the titin filaments determining “passive” …