Pathological effects of ionizing radiation: endothelial activation and dysfunction

B Baselet, P Sonveaux, S Baatout, A Aerts - Cellular and molecular life …, 2019 - Springer
The endothelium, a tissue that forms a single layer of cells lining various organs and cavities
of the body, especially the heart and blood as well as lymphatic vessels, plays a complex …

Mechanisms of vascular dysfunction evoked by ionizing radiation and possible targets for its pharmacological correction

AI Soloviev, IV Kizub - Biochemical Pharmacology, 2019 - Elsevier
Ionizing radiation (IR) leads to a variety of the cardiovascular diseases, including the arterial
hypertension. A number of studies have demonstrated that blood vessels represent …

Correction of vascular hypercontractility in spontaneously hypertensive rats using shRNAs-induced delta protein kinase C gene silencing

T Novokhatska, S Tishkin, V Dosenko… - European journal of …, 2013 - Elsevier
Potassium conductance in vascular smooth muscle (VSM) is known to be altered in arterial
hypertension. High level of protein kinase C (PKC) activity is a common feature for …

Ion transport and radioresistance

B Roth, SM Huber - Targets of Cancer Diagnosis and Treatment: Ion …, 2020 - Springer
Neoplastic transformation is associated with alterations of the ion transports across plasma
and intracellular membranes. These alterations are crucial elements of the phenotypical …

Oxidative and Nitrous Stress Underlies Vascular Malfunction Induced by Ionizing Radiation and Diabetes

A Soloviev, V Sydorenko - Cardiovascular Toxicology, 2024 - Springer
Oxidative stress results from the production of reactive oxygen species (ROS) and reactive
nitrogen species (RNS) in quantities exceeding the potential activity of the body's antioxidant …

Liposomal quercetin potentiates maxi-K channel openings in smooth muscles and restores its activity after oxidative stress

MI Melnyk, DO Dryn, LT Al Kury, AV Zholos… - Journal of liposome …, 2019 - Taylor & Francis
The effects of quercetin-loaded liposomes (PCL-Q) and their constituents, that is, free
quercetin (Q) and 'empty'phosphatidylcholine vesicles (PCL), on maxi-K channel activity …

Short‐Term Statin Treatment Reduces, and Long‐Term Statin Treatment Abolishes, Chronic Vascular Injury by Radiation Therapy

K Ait‐Aissa, X Guo, M Klemmensen, D Juhr… - Journal of the …, 2024 - ahajournals.org
Background The incidental use of statins during radiation therapy has been associated with
a reduced long‐term risk of developing atherosclerotic cardiovascular disease. We …

Protein kinase C-dependent inhibition of BKCa current in rat aorta smooth muscle cells following γ-irradiation

IV Kizub, OO Pavlova, IV Ivanova… - International journal of …, 2010 - Taylor & Francis
Purpose: The aim of this study was to estimate the effects of non-fatal whole-body γ-
irradiation on outward potassium plasma membrane conductivity in rat vascular smooth …

Plasmonic gold nanoparticles possess the ability to open potassium channels in rat thoracic aorta smooth muscles in a remote control manner

A Soloviev, A Zholos, I Ivanova, T Novokhatska… - Vascular …, 2015 - Elsevier
Colloidal gold nanoparticles (AuNPs) of~ 5 nm core size and Zeta-potential of− 35 mV,
having absorption maximum and plasmon resonance in the range of 510–570 nm, were …

[PDF][PDF] Quercetin-filled phosphatidylcholine liposomes restore abnormalities in rat thoracic aorta BKCa channel function following ionizing irradiation

A Soloviev, S Tishkin, S Kyrychenko - Acta physiologica sinica, 2009 - researchgate.net
The goal of the present study was to investigate the effects of quercetin-filled
phosphatidylcholine liposomes (PCL-Q) on the currents carried by large conductance Ca2+ …