The transmission of a complete set of chromosomes to daughter cells during cell division is
vital for development and tissue homeostasis. The spindle assembly checkpoint (SAC) …

Chromosome mis-segregation during mitosis leads to aneuploidy, which is a hallmark of
cancer and linked to cancer genome evolution. Errors can manifest as" lagging …

Kinetochores are multi-protein machines that form dynamic attachments to microtubules and
control chromosome segregation. High fidelity is ensured because kinetochores can monitor …

Cell proliferation and sexual reproduction require the faithful segregation of chromosomes.
Chromosome segregation is driven by the interaction of chromosomes with the spindle, and …

Current models infer that the microtubule-based mitotic spindle is built from GDP-tubulin with
small GTP caps at microtubule plus-ends, including those that attach to kinetochores …

To achieve chromosome segregation during mitosis, sister chromatids must undergo a
dramatic change in their behavior to switch from balanced oscillations at the metaphase …

During mitosis, tension develops across the centromere as a result of spindle-based forces.
Metaphase tension may be critical in preventing mitotic chromosome segregation errors …

Kinetochores are multi-protein complexes that mediate the physical coupling of sister
chromatids to spindle microtubule bundles (called kinetochore (K)-fibres) from respective …

Chromosome segregation is a mechanical process that requires assembly of the mitotic
spindle–a dynamic microtubule-based force-generating machine. Connections to this …

Establishment of proper chromosome attachments to the spindle requires elimination of
erroneous attachments, but the mechanism of this process is not fully understood. During …