Depression represents the number one cause of disability worldwide and is often fatal.
Inflammatory processes have been implicated in the pathophysiology of depression. It is …

Over the past two decades, compelling evidence has emerged indicating that immune
mechanisms can contribute to the pathogenesis of major depressive disorder (MDD) and …

The kynurenine pathway (KP) plays a critical role in generating cellular energy in the form of
nicotinamide adenine dinucleotide (NAD+). Because energy requirements are substantially …

Depression and obesity are common conditions with major public health implications that
tend to co-occur within individuals. The relationship between these conditions is …

BackgroundC-reactive protein (CRP) is a candidate biomarker for major depressive disorder
(MDD), but it is unclear how peripheral CRP levels relate to the heterogeneous clinical …

Introduction Meta-analyses implicate immune dysfunction in depression confirming
increased levels of circulating immune proteins (eg, cytokines) in depression cases …

Psychosocial stress has profound effects on the body, including the immune system and the
brain,. Although a large number of pre-clinical and clinical studies have linked peripheral …

Interleukein-6 (IL-6), is produced locally from infectious or injured lesions and is delivered to
the whole body via the blood stream, promptly activating the host defense system to perform …

Background While cross-sectional associations of inflammatory markers interleukin-6 (IL-6)
and C-reactive protein with major depressive disorder are well established, evidence for …

Microglia are the predominant immune response cells and professional phagocytes of the
central nervous system (CNS) that have been shown to be important for brain development …