Mesenchymal stem cells (MSC) are multipotent cells, functioning as precursors to a variety
of cell types including adipocytes, osteoblasts, and chondrocytes. Between osteogenic and …

RUNX proteins belong to a family of metazoan transcription factors that serve as master
regulators of development. They are frequently deregulated in human cancers, indicating a …

The epithelial-to-mesenchymal transition (EMT) is frequently co-opted by cancer cells to
enhance migratory and invasive cell traits. It is a key contributor to heterogeneity …

ABSTRACT RUNX transcription factors orchestrate many different aspects of biology,
including basic cellular and developmental processes, stem cell biology and tumorigenesis …

Abstract Runt-related transcription factor-1 (Runx1) is required for chondrocyte-to-osteoblast
lineage commitment by enhancing both chondrogenesis and osteogenesis during …

Abstract The Polycomb group (PcG) proteins are transcriptional repressors that regulate
lineage choices during development and differentiation. Recent studies have advanced our …

Background The detection of physiologically relevant protein isoforms encoded by the
human genome is critical to biomedicine. Mass spectrometry (MS)-based proteomics is the …

Cell differentiation involves activation and silencing of lineage-specific genes. Here we
show that the transcription factor Runx3 is induced in T helper type 1 (TH1) cells in a T-bet …

Interplay between chromatin-associated complexes and modifications critically contribute to
the partitioning of epigenome into stable and functionally distinct domains. Yet there is a lack …

It is becoming increasingly clear that short and long noncoding RNAs critically participate in
the regulation of cell growth, differentiation, and (mis) function. However, while the functional …