ABSTRACT A vast array of oncogenic variants has been identified for anaplastic lymphoma
kinase (ALK). Therefore, there is a need to better understand the role of ALK in cancer …

RTKs (receptor tyrosine kinases) play important roles in cellular proliferation and
differentiation. In addition, RTKs reveal oncogenic potential when their kinase activities are …

Regulatory protein phosphorylation controls normal and pathophysiological signaling in
eukaryotic cells. Despite great advances in mass-spectrometry-based proteomics, the …

Genetic studies have established anaplastic lymphoma kinase (ALK), a cell surface receptor
tyrosine kinase, as a tractable molecular target in neuroblastoma. We describe …

Improvement in the clinical outcome of lung cancer is likely to be achieved by identification
of the molecular events that underlie its pathogenesis. Here we show that a small inversion …

Neuroblastoma in advanced stages is one of the most intractable paediatric cancers, even
with recent therapeutic advances. Neuroblastoma harbours a variety of genetic changes …

Thyroid cancer is a common endocrine malignancy that encompasses well-differentiated as
well as dedifferentiated cancer types. The latter tumors have high mortality and lack effective …

Purpose: EML4-ALK is a fusion-type protein tyrosine kinase that is generated by inv
(2)(p21p23) in the genome of non–small cell lung cancer (NSCLC). To allow sensitive …

The genome of a subset of non–small-cell lung cancers (NSCLC) harbors a small inversion
within chromosome 2 that gives rise to a transforming fusion gene, EML4-ALK, which …

Resistance to imatinib represents an important scientific and clinical issue in chronic
myelogenous leukemia. In the present study, the effects of the novel inhibitor SKI-606 on …