Natural isoquinoline alkaloids: Pharmacological features and multi-target potential for complex diseases
Complex diseases such as neurodegenerative disorders and cancer constitute a growing
public health problem due to the rising incidence and lack in effective therapies. Since …
public health problem due to the rising incidence and lack in effective therapies. Since …
Natural products against Alzheimer's disease: Pharmaco-therapeutics and biotechnological interventions
A Dey, R Bhattacharya, A Mukherjee… - Biotechnology advances, 2017 - Elsevier
Alzheimer's disease (AD) is a severe, chronic and progressive neurodegenerative disease
associated with memory and cognition impairment ultimately leading to death. It is the …
associated with memory and cognition impairment ultimately leading to death. It is the …
Plant alkaloids as drug leads for Alzheimer's disease
YP Ng, TCT Or, NY Ip - Neurochemistry international, 2015 - Elsevier
Alzheimer's disease (AD) is a neurodegenerative illness associated with dementia and is
most prevalent among the elderly population. Current medications can only treat symptoms …
most prevalent among the elderly population. Current medications can only treat symptoms …
[HTML][HTML] Role of plant derived alkaloids and their mechanism in neurodegenerative disorders
Neurodegenerative diseases are conventionally demarcated as disorders with selective loss
of neurons. Conventional as well as newer molecules have been tested but they offer just …
of neurons. Conventional as well as newer molecules have been tested but they offer just …
Emerging therapeutic potentials of dual‐acting MAO and AChE inhibitors in Alzheimer's and Parkinson's diseases
B Mathew, DGT Parambi, GE Mathew… - Archiv der …, 2019 - Wiley Online Library
No drug has been approved to prevent neuronal cell loss in patients suffering from
Parkinson's disease (PD) or Alzheimer's disease (AD); despite increased comprehension of …
Parkinson's disease (PD) or Alzheimer's disease (AD); despite increased comprehension of …
Phytochemicals from fern species: potential for medicine applications
Ferns are an important phytogenetic bridge between lower and higher plants. Historically
they have been used in many ways by humans, including as ornamental plants, domestic …
they have been used in many ways by humans, including as ornamental plants, domestic …
[HTML][HTML] Anti-Alzheimer's disease potential of traditional chinese medicinal herbs as inhibitors of BACE1 and AChE enzymes
R Dai, Y Sun, R Su, H Gao - Biomedicine & Pharmacotherapy, 2022 - Elsevier
Alzheimer's disease (AD) is a common neurodegenerative disease that often occurs in the
elderly population. At present, most drugs for AD on the market are single-target drugs …
elderly population. At present, most drugs for AD on the market are single-target drugs …
Plant alkaloids: Structures and bioactive properties
EP Gutiérrez-Grijalva, LX López-Martínez… - Plant-derived bioactives …, 2020 - Springer
Alkaloids are nitrogen-containing natural products found in bacteria, fungi, animals, and
plants with complex and diverse structures. The widespread distribution of alkaloids along …
plants with complex and diverse structures. The widespread distribution of alkaloids along …
Cholinesterases and the fine line between poison and remedy
CN Pope, S Brimijoin - Biochemical pharmacology, 2018 - Elsevier
Abstract Acetylcholinesterase (AChE, EC 3.1. 1.7) and butyrylcholinesterase (BChE, EC 3.1.
1.8) are related enzymes found across the animal kingdom. The critical role of …
1.8) are related enzymes found across the animal kingdom. The critical role of …
Deciphering the interactions of bioactive compounds in selected traditional medicinal plants against Alzheimer's diseases via pharmacophore modeling, auto-QSAR …
Neurodegenerative diseases, for example Alzheimer's, are perceived as driven by
hereditary, cellular, and multifaceted biochemical actions. Numerous plant products, for …
hereditary, cellular, and multifaceted biochemical actions. Numerous plant products, for …