[HTML][HTML] Mammalian/mechanistic target of rapamycin (mTOR) complexes in neurodegeneration

H Querfurth, HK Lee - Molecular neurodegeneration, 2021 - Springer
Novel targets to arrest neurodegeneration in several dementing conditions involving
misfolded protein accumulations may be found in the diverse signaling pathways of the …

New insights for oxidative stress and diabetes mellitus

K Maiese - Oxidative medicine and cellular longevity, 2015 - Wiley Online Library
The release of reactive oxygen species (ROS) and the generation of oxidative stress are
considered critical factors for the pathogenesis of diabetes mellitus (DM), a disorder that is …

Cyclin B1/CDK1-regulated mitochondrial bioenergetics in cell cycle progression and tumor resistance

B Xie, S Wang, N Jiang, JJ Li - Cancer letters, 2019 - Elsevier
A mammalian cell houses two genomes located separately in the nucleus and mitochondria.
During evolution, communications and adaptations between these two genomes occur …

Targeting molecules to medicine with mTOR, autophagy and neurodegenerative disorders

K Maiese - British journal of clinical pharmacology, 2016 - Wiley Online Library
Neurodegenerative disorders are significantly increasing in incidence as the age of the
global population continues to climb with improved life expectancy. At present, more than 30 …

Photocatalytically active graphitic carbon nitride as an effective and safe 2D material for in vitro and in vivo photodynamic therapy

H Taheri, MA Unal, M Sevim, C Gurcan, O Ekim… - Small, 2020 - Wiley Online Library
Thanks to its photocatalytic property, graphitic carbon nitride (g‐C3N4) is a promising
candidate in various applications including nanomedicine. However, studies focusing on the …

FoxO proteins in the nervous system

K Maiese - Analytical cellular pathology, 2015 - Wiley Online Library
Acute as well as chronic disorders of the nervous system lead to significant morbidity and
mortality for millions of individuals globally. Given the ability to govern stem cell proliferation …

The role of mitochondria and oxidative/antioxidative imbalance in pathobiology of chronic obstructive pulmonary disease

AJ Białas, P Sitarek… - Oxidative medicine …, 2016 - Wiley Online Library
Chronic obstructive pulmonary disease (COPD) is a common preventable and treatable
disease, characterized by persistent airflow limitation that is usually progressive and …

[HTML][HTML] Fmrp interacts with adar and regulates RNA editing, synaptic density and locomotor activity in zebrafish

A Shamay-Ramot, K Khermesh, HT Porath… - PLoS …, 2015 - journals.plos.org
Fragile X syndrome (FXS) is the most frequent inherited form of mental retardation. The
cause for this X-linked disorder is the silencing of the fragile X mental retardation 1 (fmr1) …

[HTML][HTML] Novel nervous and multi-system regenerative therapeutic strategies for diabetes mellitus with mTOR

K Maiese - Neural regeneration research, 2016 - journals.lww.com
Throughout the globe, diabetes mellitus (DM) is increasing in incidence with limited
therapies presently available to prevent or resolve the significant complications of this …

Taking aim at Alzheimer's disease through the mammalian target of rapamycin

K Maiese - Annals of medicine, 2014 - Taylor & Francis
A significant portion of the world's population suffers from sporadic Alzheimer's disease (AD)
with available present therapies limited to symptomatic care that does not alter disease …