Behaviours of complex biomolecular systems are often irreducible to the elementary
properties of their individual components. Explanatory and predictive mathematical models …

Cell death plays an essential role in the development of tissues and organisms, the etiology
of disease, and the responses of cells to therapeutic drugs. Here we review progress made …

Prostate cancer is the second most occurring cancer in men worldwide. To better
understand the mechanisms of tumorigenesis and possible treatment responses, we …

The Mitogen-Activated Protein Kinase (MAPK) network consists of tightly interconnected
signalling pathways involved in diverse cellular processes, such as cell cycle, survival …

The tremendous amount of the data obtained from the study of complex biological systems
changes our view on the pathogenesis of human diseases. Instead of looking at individual …

Motivation Due to the complexity and heterogeneity of multicellular biological systems,
mathematical models that take into account cell signalling, cell population behaviour and the …

Background Qualitative frameworks, especially those based on the logical discrete
formalism, are increasingly used to model regulatory and signalling networks. A major …

Cancers of the breast and other tissues arise from aberrant decision-making by cells
regarding their survival or death, proliferation or quiescence, damage repair or bypass …

Discovery of efficient anti-cancer drug combinations is a major challenge, since
experimental testing of all possible combinations is clearly impossible. Recent efforts to …

In the clinic, proton beam therapy (PBT) is based on the use of a generic relative biological
effectiveness (RBE) of 1.1 compared to photons in human cancers and normal tissues …