50 years of oral lipid-based formulations: provenance, progress and future perspectives
Lipid based formulations (LBF) provide well proven opportunities to enhance the oral
absorption of drugs and drug candidates that sit close to, or beyond, the boundaries of …
absorption of drugs and drug candidates that sit close to, or beyond, the boundaries of …
In vitro digestion models to evaluate lipid based drug delivery systems; present status and current trends
During the past two decades, a range of in vitro models simulating the digestion processes
occurring in the stomach and small intestine have been developed to characterize lipid …
occurring in the stomach and small intestine have been developed to characterize lipid …
[HTML][HTML] In vitro and in vivo correlation for lipid-based formulations: Current status and future perspectives
Lipid-based formulations (LBFs) have demonstrated a great potential in enhancing the oral
absorption of poorly water-soluble drugs. However, construction of in vitro and in vivo …
absorption of poorly water-soluble drugs. However, construction of in vitro and in vivo …
[HTML][HTML] Leveraging the use of in vitro and computational methods to support the development of enabling oral drug products: An InPharma commentary
Due to the strong tendency towards poorly soluble drugs in modern development pipelines,
enabling drug formulations such as amorphous solid dispersions, cyclodextrins, co-crystals …
enabling drug formulations such as amorphous solid dispersions, cyclodextrins, co-crystals …
Extensive improvement of oral bioavailability of mebendazole, a brick dust, by polymer-containing SNEDDS preparation: Disruption of high crystallinity by utilizing its …
Y Sumimoto, S Okawa, T Inoue, K Masuda… - European Journal of …, 2022 - Elsevier
Poorly water-soluble and poorly lipid-soluble drugs are called as “brick dust” and it is very
hard for them to be formulated as some dosage form which can provide an effective …
hard for them to be formulated as some dosage form which can provide an effective …
Hypolipidemic potential of perillaldehyde-loaded self-nanoemulsifying delivery system in high-fat diet induced hyperlipidemic mice: formulation, in vitro and in vivo …
E Omari-Siaw, Y Zhu, H Wang, W Peng… - European Journal of …, 2016 - Elsevier
This study reports the hypolipidemic effects of perillaldehyde-loaded self-nanoemulsifying
delivery system (PAH-SNEDS) developed with D-optimal experimental design based on a …
delivery system (PAH-SNEDS) developed with D-optimal experimental design based on a …
Improvement of lipid solubility and oral bioavailability of a poorly water-and poorly lipid-soluble drug, rebamipide, by utilizing its counter ion and SNEDDS preparation
S Okawa, Y Sumimoto, K Masuda, K Ogawara… - European Journal of …, 2021 - Elsevier
Among drugs in development and/or in market, there are poorly water-soluble and poorly
lipid-soluble compounds. Rebamipide, classified into BCS class IV, is one of those drugs …
lipid-soluble compounds. Rebamipide, classified into BCS class IV, is one of those drugs …
Incorporation of lipolysis in monolayer permeability studies of lipid-based oral drug delivery systems
T Sadhukha, B Layek, S Prabha - Drug Delivery and Translational …, 2018 - Springer
Lipid-based drug delivery systems, a well-tolerated class of formulations, have been
evaluated extensively to enhance the bioavailability of poorly soluble drugs. However, it has …
evaluated extensively to enhance the bioavailability of poorly soluble drugs. However, it has …
Trends in the assessment of drug supersaturation and precipitation in vitro using lipid-based delivery systems
C Stillhart, M Kuentz - Journal of pharmaceutical sciences, 2016 - Elsevier
The generation of drug supersaturation close to the absorptive site is an important
mechanism of how several formulation technologies enhance oral absorption and …
mechanism of how several formulation technologies enhance oral absorption and …
Development of lipid-based SEDDS using digestion products of long-chain triglyceride for high drug solubility: Formulation and dispersion testing
HH Desai, ATM Serajuddin - International Journal of Pharmaceutics, 2024 - Elsevier
A self-emulsifying drug delivery system (SEDDS) containing long chain lipid digestion
products (LDP) and surfactants was developed to increase solubility of two model weakly …
products (LDP) and surfactants was developed to increase solubility of two model weakly …