Transient receptor potential (TRP) channels are sensors for a variety of cellular and
environmental signals. Mammals express a total of 28 different TRP channel proteins, which …

The skin is a complex organ that has devised numerous strategies, such as physical,
chemical, and microbiological barriers, to protect the host from external insults. In addition …

The skin is the outermost organ of the body and is continuously exposed to external
pathogens. Upon inflammation, various immune cells pass through, reside in or are …

Microglia, resident macrophages of the CNS, are essential to brain development,
homeostasis, and disease. Microglial activation and proliferation are hallmarks of many CNS …

The nervous system regulates immunity and inflammation. The molecular detection of
pathogen fragments, cytokines, and other immune molecules by sensory neurons generates …

Osteoarthritis (OA) is the major course of joint deterioration, in which M1 macrophage-driven
synovitis exacerbates the pathological process. However, precise therapies for M1 …

Itch is an evolutionarily conserved sensation that facilitates expulsion of pathogens and
noxious stimuli from the skin. However, in organ failure, cancer, and chronic inflammatory …

Process of inflammation and complex interactions between immune and cancer cells within
tumor microenvironment are known to drive and shape the outcome of the neoplastic …

Atopic dermatitis (AD) is a common, chronic-relapsing inflammatory skin disease with
significant disease burden. Genetic and environmental trigger factors contribute to AD …

Cutaneous TRPV1+ neurons directly sense noxious stimuli, inflammatory cytokines, and
pathogen-associated molecules and are required for innate immunity against some skin …