The biochemical role of the PI3K/PKB/mTOR signalling pathway in cell-cycle regulation is
now well known. During the onset and development of different forms of cancer it becomes …

Nutrients such as glucose, amino acids and lipids are fundamental sources for the
maintenance of essential cellular processes and homeostasis in all organisms. The nutrient …

The promising anti-angiogenetic properties of previously synthesized pyrazolyl ureas
provided the rationale for the synthesis of novel 5-aminopyrazoles 2–5, differently decorated …

The mammalian target of rapamycin (mTOR) is a highly conserved serine/threonine-protein
kinase, which regulates many biological processes related to metabolism, cancer, immune …

This study aims to identify the international technology trends and convergence structures
that emerged during the coronavirus disease (COVID-19) pandemic by analyzing COVID-19 …

Abstract Phosphoinositide 3-kinases (PI3K) and phosphoinositide 3-kinase-related protein
kinases (PIKK) are two structurally related families of kinases that play vital roles in cell …

Metformin has been used for ages to treat diabetes mellitus due to its safety profile and low
cost. However, metformin has variable pharmacokinetics in patients, and due to its poor oral …

Autophagy, a crucial intracellular degradation process facilitated by lysosomes, plays a
pivotal role in maintaining cellular homeostasis. The elucidation of autophagy key genes …

The progressive aging of the population and the fact that Parkinson's disease currently does
not have any curative treatment turn out to be essential issues in the following years, where …

Abstract Activated phosphoinositide-3-kinase (PI3K) δ syndrome (APDS) is an inborn error
of immunity characterised by immune dysregulation. Since the discovery of genetic …