Fluoride in the Central Nervous System and its potential influence on the development and invasiveness of brain tumours—A Research hypothesis

W Żwierełło, A Maruszewska… - International Journal of …, 2023 - mdpi.com
The purpose of this review is to attempt to outline the potential role of fluoride in the
pathogenesis of brain tumours, including glioblastoma (GBM). In this paper, we show for the …

Effect of fluoride on cytotoxicity involved in mitochondrial dysfunction: a review of mechanism

M Wei, Y Ye, MM Ali, Y Chamba, J Tang… - Frontiers in veterinary …, 2022 - frontiersin.org
Fluoride is commonly found in the soil and water environment and may act as chronic
poison. A large amount of fluoride deposition causes serious harm to the ecological …

Novel pathways of fluoride-induced hepatotoxicity: P53-dependent ferroptosis induced by the SIRT1/FOXOs pathway and Nrf2/HO-1 pathway

D Wang, K Yin, Y Zhang, H Lu, L Hou, H Zhao… - … and Physiology Part C …, 2023 - Elsevier
Fluoride (F) is an environmental pollutant that continues to threaten human health. Long-
term or excessive fluoride exposure can cause a series of acute or chronic systemic and …

Fluoride induced neurobehavioral impairments in experimental animals: a brief review

H Ottappilakkil, S Babu, S Balasubramanian… - … Trace Element Research, 2023 - Springer
Fluoride is one of the major toxicants in the environment and is often found in drinking water
at higher concentrations. Living organisms including humans exposed to high fluoride levels …

Effects of fluoride exposure on mitochondrial function: energy metabolism, dynamics, biogenesis and mitophagy

SH Avila-Rojas, OE Aparicio-Trejo… - Environmental …, 2022 - Elsevier
Fluoride is ubiquitous in the environment. Furthermore, drinking water represents the main
source of exposure to fluoride for humans. Interestingly, low fluoride concentrations have …

Smart Hesperidin/Chitosan Nanogel Mitigates Apoptosis and Endoplasmic Reticulum Stress in Fluoride and Aluminum-Induced Testicular Injury

NS Deiab, AS Kodous, MK Mahfouz, AM Said… - … Trace Element Research, 2024 - Springer
Fluoride and aluminum are ubiquitous toxic metals with adverse reproductive effects. The
citrus flavonoid hesperidin has protective activities but poor solubility and bioavailability …

[HTML][HTML] The inhibition of TRPML1/TFEB leads to lysosomal biogenesis disorder, contributes to developmental fluoride neurotoxicity

J Zhang, Y Tang, Z Hu, W Xu, Y Ma, P Xu… - Ecotoxicology and …, 2023 - Elsevier
Fluoride is capable of inducing developmental neurotoxicity; regrettably, the mechanism is
obscure. We aimed to probe the role of lysosomal biogenesis disorder in developmental …

[HTML][HTML] Epigallocatechin-3-gallate attenuates fluoride induced apoptosis via PI3K/FoxO1 pathway in ameloblast-like cells

Q Zhang, X Fei, Y Li, H Zhang, L Chen, J Ruan, N Dong - Toxicon, 2024 - Elsevier
Fluoride is a double-edged sword. It was widely used for early caries prevention while
excessive intake caused a toxicology effect, affected enamel development, and resulted in …

[HTML][HTML] Fluoride regulates the differentiation and atrophy through FGF21/ERK signaling pathway in C2C12 cells

L Ma, C Zhang, Y Gui, T Zou, S Xi, X Guo - … and Environmental Safety, 2023 - Elsevier
Excess intake of fluoride leads to a serious health issue called fluorosis. Fluorosis patients
exhibit the symptom of muscle damage, but the specific mechanism remains unclear …

Hydrothermal synthesis of fluorapatite coatings over titanium implants for enhanced osseointegration—An in vivo study in the rabbit

E Santiago, V Martin, B Colaço, MH Fernandes… - Journal of functional …, 2022 - mdpi.com
This work aims at the development and characterization of fluorapatite coatings, innovatively
prepared by the hydrothermal method, aiming for enhanced osseointegration of titanium …